Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology and Hepatology
Volume 2017, Article ID 3689375, 6 pages
https://doi.org/10.1155/2017/3689375
Research Article

Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity

Laboratorio de Espectrometría de Masas, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, Mexico

Correspondence should be addressed to Jorge Maldonado-Hernández; xm.moc.oohay@hmroj

Received 7 February 2017; Accepted 16 April 2017; Published 28 May 2017

Academic Editor: Kevork M. Peltekian

Copyright © 2017 Jorge Maldonado-Hernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Aburasayn, R. Al Batran, and J. R. Ussher, “Targeting ceramide metabolism in obesity,” American Journal of Physiology, Endocrinology and Metabolism, vol. 311, pp. 423–435, 2016. View at Google Scholar
  2. R. Kolesnick, “The therapeutic potential of modulating the ceramide/sphingomyelin pathway,” Journal of Clinical Investigation, vol. 110, no. 1, pp. 3–8, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Chaurasia and S. A. Summers, “Ceramides—lipotoxic inducers of metabolic disorders,” Trends in Endocrinology and Metabolism, vol. 26, no. 10, pp. 538–550, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. W. L. Holland and S. A. Summers, “Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism,” Endocrine Reviews, vol. 29, no. 4, pp. 381–402, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Marí and J. C. Fernández-Checa, “Sphingolipid signalling and liver diseases,” Liver International, vol. 27, no. 4, pp. 440–450, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Amati, J. J. Dubé, E. Alvarez-Carnero et al., “Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?” Diabetes, vol. 60, no. 10, pp. 2588–2597, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Chavez and S. A. Summers, “A ceramide-centric view of insulin resistance,” Cell Metabolism, vol. 15, no. 5, pp. 585–594, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. P. J. Larsen and N. Tennagels, “On ceramides, other sphingolipids and impaired glucose homeostasis,” Molecular Metabolism, vol. 3, no. 3, pp. 252–260, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Pagadala, T. Kasumov, A. J. McCullough, N. N. Zein, and J. P. Kirwan, “Role of ceramides in nonalcoholic fatty liver disease,” Trends in Endocrinology and Metabolism, vol. 23, no. 8, pp. 365–371, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. M. N. Nikolova-Karakashian and K. A. Rozenova, “Ceramide in stress response,” Advances in Experimental Medicine and Biology, vol. 688, pp. 86–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Lightle, R. Tosheva, A. Lee et al., “Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: Role of serine-palmitoyl transferase,” Archives of Biochemistry and Biophysics, vol. 419, no. 2, pp. 120–128, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Botros and K. A. Sikaris, “The de ritis ratio: the test of time,” The Clinical Biochemist Reviews, vol. 34, pp. 117–130, 2013. View at Google Scholar
  13. R. Loomba, C. B. Sirlin, J. B. Schwimmer, and J. E. Lavine, “Advances in pediatric nonalcoholic fatty liver disease,” Hepatology, vol. 50, no. 4, pp. 1282–1293, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Salas-Fernández, J. Maldonado-Hernández, A. Martínez-Basila, G. Martínez-Razo, and F. Jasso-Saavedra, “The 13C-glucose breath test is a valid non-invasive screening tool to identify metabolic syndrome in adolescents,” Clinical Chemistry and Laboratory Medicine, vol. 53, no. 1, pp. 133–138, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. M. López-Alarcón, O. Perichart-Perera, S. Flores-Huerta et al., “Excessive refined carbohydrates and scarce micronutrients intakes increase inflammatory mediators and insulin resistance in prepubertal and pubertal obese children independently of obesity,” Mediators of Inflammation, vol. 2014, Article ID 849031, 7 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Kasumov, H. Huang, Y.-M. Chung, R. Zhang, A. J. McCullough, and J. P. Kirwan, “Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry,” Analytical Biochemistry, vol. 401, no. 1, pp. 154–161, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. de Onis and A. W. Onyango, “WHO child growth standards,” The Lancet, vol. 371, no. 9608, p. 204, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Tomita, T. Teratani, H. Yokoyama et al., “Plasma free myristic acid proportion is a predictor of nonalcoholic steatohepatitis,” Digestive Diseases and Sciences, vol. 56, no. 10, pp. 3045–3052, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Lopez, A. B. Goldfine, W. L. Holland, R. Gordillo, and P. E. Scherer, “Plasma ceramides are elevated in female children and adolescents with type 2 diabetes,” Journal of Pediatric Endocrinology and Metabolism, vol. 26, no. 9-10, pp. 995–998, 2013. View at Publisher · View at Google Scholar · View at Scopus