Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
Table 1
Biochemical characteristics of study subjects.
Normal weight ()
Obesity ()
Obesity + HS ()
Gender (female/male)
8/10
17/17
16/26
Age (years)
14 (12.75–15)
12
13.5
BMI (kg/m2)
20 (19–20.6)
26.8
30.1
AST (U/L)
31 (27–38.5)
39 (29.5–47.5)
37.5 (25–56)
ALT (U/L)
19 (16–22.5)
31
54.5
Ratio (AST/ALT)
1.7 (1.4–1.8)
1.3
0.7
Triglycerides (mg/dL)
82 (62.8–98.3)
114
135.5
Cholesterol (mg/dL)
151.5 (133.5–171)
159 (145.5–187.5)
161 (144.8–185.3)
HDL (mg/dL)
54.5 (48–60)
46
47.5 (38–54)
VLDL (mg/dL)
16 (12.5–19.5)
23
29
Fating glucose (mg/dL)
84 (78–86)
87 (81–93.5)
87.5
Fasting insulin (μU/mL)
9.6 (7.5–14.7)
18.4
19
HOMA-IR
2.03 (1.6–2.9)
4.11
4.12
Data are presented as median (percentile 25–percentile 75). Comparison between groups was made with a Mann–Whitney test. difference () between obesity and normal weight group; obesity + HS and normal weight group; obesity + HS and obesity group. HOMA-IR: Homeostasis Model Assessment for Insulin Resistance.
