Canadian Journal of Gastroenterology and Hepatology / 2017 / Article / Tab 3

Research Article

Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups

Table 3

Histological criteria evaluating the degree/stage of eosinophil-rich inflammation.

(1)Eosinophilic microabscesses (MAB)Four or more eosinophils clustered together.

(2)Superficial layering of eosinophils (SLE)Superficial infiltrate of eosinophils (>1 eosinophil at ×400).

(3)Epithelial desquamation (ED)Degenerative (i.e., necrotic, pyknotic-dense, and dark nuclei because of nuclear shrinkage due to irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis, dyskeratotic-deep pink cytoplasm due to abnormal keratinization occurring prematurely within individual cells, or groups of cells below the stratum granulosum) squamous epithelial cells.

(4)Basal zone hyperplasia (BZH)Basal cells occupying more than 20% of total mucosal thickness.

(5)Rete peg elongation (RPE)Rete peg elongation that reaches at least 2/3 of total mucosal thickness.

(6)Spongiosis (SP)Edema or dilated intercellular spaces between epithelial cells.

(7)Subepithelial fibrosis or lamina propria fibrosis (FB)Evaluated if lamina propria was present in the specimen; collagen fibrils are densely packed and individual collagen fibrils cannot be distinguished.

(8)Degree of involvement of eosinophils (DFE)Focal or diffuse; focal is defined as when eosinophils are localized to one fragment of the biopsy while diffuse is when eosinophils are found >1 fragment of the biopsy.

(9)Pattern of distribution of eosinophils if present (E-Dist)Eosinophils confined to or around rete pegs (peripapillary), diffusely distributed, or superficially distributed.

(10)Eosinophilic degranulation (DE)Presence of free eosinophil granules.