Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology and Hepatology
Volume 2017 (2017), Article ID 6070135, 5 pages
Research Article

Diagnostic Accuracy of Platelet Count and Platelet Indices in Noninvasive Assessment of Fibrosis in Nonalcoholic Fatty Liver Disease Patients

1Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia, 11000 Belgrade, Serbia
2Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
3Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA
4Mayo Clinic Health System, Eau Claire, WI, USA

Correspondence should be addressed to Tamara Milovanovic Alempijevic

Received 6 September 2017; Accepted 3 December 2017; Published 31 December 2017

Academic Editor: Dan Dumitrascu

Copyright © 2017 Tamara Milovanovic Alempijevic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Keeping in mind the rising prevalence of nonalcoholic fatty liver disease (NAFLD) and the need to establish noninvasive tests for its detection, the aim of our study was to investigate whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) can predict the presence of liver fibrosis in this group of patients. Methods. In 98 patients with NAFLD and 60 healthy volunteers, complete blood counts with automated differential counts were performed and values of PC, PDW, MPV, and PCT were analyzed. Results. Patients with NAFLD had lower PC and higher MPV, PCT, and PDW compared to the controls ( < 0.05). When NAFLD group was stratified according to severity of liver fibrosis, there was a statistically significant difference in the average values of PDW and PC between the groups ( < 0.05). Conclusion. Patients with NAFLD have significantly higher values of PCT, PDW, and MPV when compared to the healthy controls. Further studies are needed to establish their potential use for prediction of the degree of liver steatosis and fibrosis in NAFLD patients.