Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells

Figure 7

ACS5 affects CRC cells growth and metastasis through the modulation of survivin and CD44 expression. ((a), (b), (c), (e), (g)) The downregulation of ACS5 in HT29 and SW480 cells resulted in a significant reduction in survivin and CD44 expression and striking increase in caspase-3 and E-cadherin expression. ((a), (b), (d), (f), (h)) The expression of survivin and CD44 was significantly elevated, while the levels of caspase-3 and E-cadherin expression were markedly decreased in ACS5 overexpressed SW620 and LOVO cells. versus negative control or blank control group. BL, blank control; NC, negative control; siACS5, ACS5 siRNA; pACS5, pcDNA3.1(+)-ACS5.

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