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Canadian Journal of Gastroenterology and Hepatology
Volume 2017, Article ID 9456897, 8 pages
Research Article

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

1Micronutrients Research Center, Federal University of Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, Brazil
2Multidisciplinary Center of Bariatric and Metabolic Surgery, 22280-020 Rio de Janeiro, RJ, 22280-020, Brazil

Correspondence should be addressed to Adryana Cordeiro; moc.liamg@anayrdaoriedroc

Received 15 February 2017; Revised 24 April 2017; Accepted 25 May 2017; Published 8 June 2017

Academic Editor: Kevork M. Peltekian

Copyright © 2017 Adryana Cordeiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. Methods. Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m2), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. Results. The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m2 and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis () and steatohepatitis (). All individuals with steatohepatitis presented VDD (). Conclusion. The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses.