Increased CCR<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.2551994pt" id="M1" height="16.3878pt" version="1.1" viewBox="-0.0657574 -16.1326 19.1036 16.3878" width="19.1036pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-223" d="M463 623H53C46 580 40 529 27 451H59C87 510 95 515 162 515H378C293 352 192 176 75 1L82 -12L186 0C277 205 377 410 472 611L463 623Z"/></g><g transform="matrix(.012,0,0,-0.012,8.56,-7.578)"><path id="g187-109" d="M270 0V32C208 38 203 43 203 110V703C146 688 72 674 15 667V637C70 630 75 628 75 567V110C75 45 70 41 10 32V0H270Z"/></g><g transform="matrix(.012,0,0,-0.012,11.972,-7.578)"><path id="g187-112" d="M269 454C157 454 30 372 30 211C30 102 107 -12 264 -12C381 -12 496 68 496 229C496 349 408 454 269 454ZM254 415C318 415 353 338 353 199C353 51 313 27 275 27C212 27 173 124 173 247C173 361 213 415 254 415Z"/></g></svg>PD-<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06569862pt" id="M2" height="16.1983pt" version="1.1" viewBox="-0.0657574 -16.1326 17.3502 16.1983" width="17.3502pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-213" d="M345 0V33C260 38 258 46 258 122V635C174 612 105 594 35 583V554L87 550C124 546 130 539 130 494V122C130 46 127 38 42 33V0H345Z"/></g><g transform="matrix(.012,0,0,-0.012,6.373,-7.578)"><path id="g187-105" d="M531 0V32C480 40 474 41 474 105V288C474 398 423 454 336 454C286 454 237 424 203 390V703C143 688 72 674 19 667V637C71 631 75 632 75 571V105C75 41 69 38 12 32V0H249V32C207 38 203 46 203 101V352C225 373 251 380 275 380C314 380 347 354 347 277V101C347 46 344 39 296 32V0H531Z"/></g><g transform="matrix(.012,0,0,-0.012,12.98,-7.578)"><path id="g187-106" d="M148 517C189 517 220 549 220 587C220 627 189 657 149 657C111 657 78 627 78 587C78 549 111 517 148 517ZM285 0V32C225 39 220 45 220 114V454C164 438 98 425 37 418V389C85 381 92 378 92 312V114C92 43 86 39 28 32V0H285Z"/></g></svg>CXCR<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.2552004pt" id="M3" height="13.7594pt" version="1.1" viewBox="-0.0657574 -13.5042 16.0825 13.7594" width="16.0825pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-161" d="M137 515H396L428 613L422 623H104L59 307C80 314 123 327 169 327C260 327 316 267 316 175C316 98 286 45 221 45C166 45 118 84 94 106C81 117 70 121 59 112C41 99 27 77 27 61C27 46 32 36 52 20C73 2 115 -12 155 -12C216 -11 287 14 343 54C413 104 444 164 444 227C444 316 371 399 243 399C217 399 160 384 111 365L137 515Z"/></g><g transform="matrix(.012,0,0,-0.012,8.337,-7.578)"><path id="g187-44" d="M530 221V286H326V485H252V286H47V221H252V0H326V221H530Z"/></g></svg>CD<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06569958pt" id="M4" height="13.5699pt" version="1.1" viewBox="-0.0657574 -13.5042 16.7543 13.5699" width="16.7543pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-166" d="M496 176V231H406V629H337C242 511 133 363 25 211V176H279V113C279 53 274 40 189 33V0H487V33C413 40 406 49 406 109V176H496ZM279 231H103C166 334 228 422 277 488H279V231Z"/></g><g transform="matrix(.012,0,0,-0.012,9.008,-7.578)"><use xlink:href="#g187-44"/></g></svg> T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection

<div>Frequencies of CCR<svg height="12.3641pt" id="M61" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -12.1577 13.9766 12.3641" width="13.9766pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M447 623H65C61 580 56 530 47 475H76C100 541 106 550 172 550H388C308 376 196 170 91 -1L98 -12L172 -2C268 204 360 408 455 611L447 623Z" id="g113-56"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.242,-5.741)"><path d="M244 0V30C178 35 170 41 170 107V710C136 697 72 680 18 675V647C83 642 89 639 89 572V107C89 43 80 35 16 30V0H244Z" id="g58-106"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.608,-5.741)"><path d="M262 451C169 451 38 375 38 210C38 98 121 -12 261 -12C360 -12 481 64 481 227C481 351 386 451 262 451ZM249 414C337 414 385 320 385 204C385 70 333 25 272 25C189 25 134 117 134 241C134 355 189 414 249 414Z" id="g58-109"></path></g></svg>PD-<svg height="12.2075pt" id="M62" style="vertical-align:-0.04980087pt" version="1.1" viewbox="-0.0498162 -12.1577 14.342 12.2075" width="14.342pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M522 0V30C462 35 455 41 455 106V280C455 397 397 451 314 451C262 451 206 414 171 379V710C131 698 69 682 20 675V647C87 642 90 637 90 574V106C90 41 80 35 20 30V0H236V30C176 35 171 43 171 106V339C198 371 237 391 276 391C341 391 374 350 374 269V106C374 43 367 35 308 30V0H522Z" id="g58-102"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.19,-5.741)"><path d="M138 535C169 535 191 560 191 589C191 620 168 644 139 644S85 620 85 589C85 560 110 535 138 535ZM257 0V30C192 35 185 43 185 109V453C142 435 94 422 40 414V386C101 378 104 372 104 311V109C104 41 97 35 33 30V0H257Z" id="g58-103"></path></g></svg>CXCR5<sup>+</sup>CD4<sup>+</sup> T cells among all CXCR5<sup>+</sup>CD4<sup>+</sup>CD3<sup>+</sup> cells in the people with normal ALT and raised ALT. Difference between two group was significant (p&lt;0.001). The horizontal lines show the median.</div>

Canadian Journal of Gastroenterology and Hepatology

fig4

Figure 4

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Figure 4 | Increased CCRPD-CXCRCD T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection 