A 43-year-old male presented with fever and right abdominal pain for five days. (a) Enhanced CT shows a lager multiloculated liver abscess in the right hepatic lobe. The abscess cavity has gas formation, which is associated with mortality. (b) Catheter was placed under CT guidance. (c) After the pus was pulled out, oxygen-ozone gas mixture was given through catheter and filled the small locules of the abscesses; some separation was broken. (d) Abscess was absorbed after three weeks.