Canadian Journal of Gastroenterology and Hepatology

Research Article

Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy

Table 3

Univariate and multivariate analysis of predictive factors of PHLF, major morbidity, and 30-day mortality after extended hepatectomy.

(a) PHLF


Variables	Univariate			Multivariate
Variables	OR	95% CI	p	OR	95% CI	p

Age	1.015	0.988–1.043	0.280
Gender	0.963	0.523–1.772	0.902
BMI (kg/m²)	0.989	0.914–1.071	0.793
ASA score	1.429	0.743–2.751	0.285

Indication of extended hepatectomy
Benign liver disease	Reference	Reference	Reference	Reference	Reference	Reference
Primary malignancy	1.367	0.256–7.290	0.714	0.810	0.120–5.470	0.828
Metastatic disease	2.306	1.159–4.591	0.017	1.897	0.806–4.463	0.141
Preoperative chemotherapy	1.679	0.723–3.896	0.228
Platelet count <150 x 10⁹/L	4.658	1.678–12.929	0.003	4.351	1.266–14.953	0.020

Intraoperative blood loss (L)	1.159	1.036–1.297	0.010	0.884	0.615–1.271	0.506
Intraoperative RBC/FFP transfusion	2.617	1.343–5.098	0.005	2.226	0.859–5.769	0.099
Operation time (hour)	1.264	1.076–1.484	0.004	1.167	0.961–1.417	0.120

(b) Major morbidity


Variables	Univariate			Multivariate
Variables	OR	95% CI	p	OR	95% CI	p

Age	1.036	1.010–1.062	0.006	1.050	1.020–1.083	0.001
Gender	1.148	0.669–1.969	0.617
BMI (kg/m²)	1.011	0.944–1.083	0.758
ASA score	1.329	0.752–2.346	0.328

Indication of extended hepatectomy
Benign liver disease	Reference	Reference	Reference	Reference	Reference	Reference
Primary malignancy	2.017	0.497–8.187	0.326	1.347	0.195–9.291	0.762
Metastatic disease	3.331	1.827–6.072	<0.001	2.387	1.111–5.127	0.026
Preoperative chemotherapy	0.626	0.274–1.428	0.266
Platelet count <150 x 10⁹/L	10.427	2.321–46.845	0.002	4.923	0.922–26.296	0.062

Intraoperative blood loss (L)	1.365	1.181–1.577	<0.001	1.309	0.863–1.985	0.206
Intraoperative RBC/FFP transfusion	2.880	1.555–5.336	0.001	1.285	0.491–3.363	0.610
Operation time (hour)	1.431	1.215–1.685	<0.001	1.237	1.007–1.520	0.042

(c) 30-day mortality


Variables	Univariate			Multivariate
Variables	OR	95% CI	p	OR	95% CI	p

Age	1.038	0.997–1.082	0.073	1.038	0.994–1.085	0.094
Gender	1.720	0.718–4.124	0.224
BMI (kg/m²)	1.032	0.928–1.147	0.564
ASA score	1.179	0.504–2.762	0.704

Indication of extended hepatectomy
Benign liver disease	Reference	Reference	Reference	Reference	Reference	Reference
Primary malignancy	2.406	0.239–24.220	0.456	1.784	0.078–40.796	0.717
Metastatic disease	3.517	1.150–10.754	0.027	3.460	0.856–13.980	0.081
Preoperative chemotherapy	0.570	0.126–2.568	0.464
Platelet count <150 x 10⁹/L	5.394	1.784–16.311	0.003	4.430	1.055–18.777	0.043

Intraoperative blood loss (L)	1.342	1.085–1.659	0.007	1.166	0.753–1.805	0.492
Intraoperative RBC/FFP transfusion	3.216	1.295–7.986	0.012	1.604	0.435–5.921	0.478
Operation time (hour)	1.261	1.023–1.555	0.030	1.093	0.839–1.425	0.509

OR: odds ratio; CI: confidence interval; BMI: body mass index; ASA: American Society of Anesthesiologists; RBC: red blood cells; FFP: fresh-frozen plasma.