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Canadian Journal of Gastroenterology and Hepatology
Volume 2018, Article ID 1531958, 13 pages
Review Article

Choosing an Animal Model for the Study of Functional Dyspepsia

1Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China
2Beijing University of Chinese Medicine, Beijing, China

Correspondence should be addressed to Cun-Zhi Liu; moc.621@087326zcl

Received 9 September 2017; Accepted 16 November 2017; Published 12 February 2018

Academic Editor: Yousuke Nakai

Copyright © 2018 Yang Ye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Functional dyspepsia (FD) is a common functional gastrointestinal disorder with pain or discomfort in the upper abdomen as the main characteristic. The prevalence of FD worldwide varies between 5% and 11%. This condition adversely affects attendance and productivity in the workplace. Emerging evidence is beginning to unravel the pathophysiologies of FD, and new data on treatment are helping to guide evidence-based practice. In order to better understand the pathophysiologies of FD and explore better treatment options, various kinds of animal models of FD have been developed. However, it is unclear which of these models most closely mimic the human disease. This review provides a comprehensive overview of the currently available animal models of FD in relationship to the clinical features of the disease. The rationales, methods, merits, and disadvantages for modelling specific symptoms of FD are discussed in detail.