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Canadian Journal of Gastroenterology and Hepatology
Volume 2018, Article ID 1531958, 13 pages
https://doi.org/10.1155/2018/1531958
Review Article

Choosing an Animal Model for the Study of Functional Dyspepsia

1Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China
2Beijing University of Chinese Medicine, Beijing, China

Correspondence should be addressed to Cun-Zhi Liu; moc.621@087326zcl

Received 9 September 2017; Accepted 16 November 2017; Published 12 February 2018

Academic Editor: Yousuke Nakai

Copyright © 2018 Yang Ye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. J. Talley, G. R. Locke III, and B. D. Lahr, “Functional dyspepsia, delayed gastric emptying, and impaired quality of life,” Gut, vol. 55, no. 7, pp. 933–939, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. C. Ford, A. Marwaha, R. Sood, and P. Moayyedi, “Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis,” Gut, vol. 64, pp. 1049–1057, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. N. J. Talley and A. C. Ford, “Functional dyspepsia,” The New England Journal of Medicine, vol. 373, no. 19, pp. 1853–1863, 2015. View at Publisher · View at Google Scholar
  4. M. Camilleri, L. Bueno, and V. Andresen, “Pharmacological, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders,” Gastroenterology, 2016. View at Google Scholar
  5. G. F. Longstreth, “Functional dyspepsia - managing the conundrum,” The New England Journal of Medicine, vol. 354, no. 8, pp. 791–793, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Matsunaga, T. Tanaka, K. Yoshinaga et al., “Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride,” The Journal of Pharmacology and Experimental Therapeutics, vol. 336, no. 3, pp. 791–800, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Kawachi, Y. Matsunaga, T. Tanaka et al., “Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats,” European Journal of Pharmacology, vol. 666, no. 1-3, pp. 218–225, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Nagahama, Y. Matsunaga, M. Kawachi et al., “Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious dogs,” Neurogastroenterology & Motility, vol. 24, no. 6, pp. 566–e256, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Asano, S. Aida, S. Suemasu, and T. Mizushima, “Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents,” Biochemical and Biophysical Research Communications, vol. 472, no. 1, pp. 125–130, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Kimura and M. Sumiyoshi, “Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice,” Journal of Ethnopharmacology, vol. 141, no. 1, pp. 530–536, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. T. H. Lee, J. J. Choi, D. H. Kim et al., “Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber,” Phytomedicine, vol. 15, no. 10, pp. 836–843, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. T. H. Lee, M. Son, and S. Y. Kim, “Effects of corydaline from corydalis tuber on gastric motor function in an animal model,” Biological & Pharmaceutical Bulletin, vol. 33, no. 6, pp. 958–962, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. T. H. Lee, K. H. Kim, S. O. Lee, K. R. Lee, M. Son, and M. Jin, “Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function,” The Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 3, pp. 917–924, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Hirata, Y. Keto, M. Yamano, T. Yokoyama, T. Sengoku, and N. Seki, “Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats,” Journal of Gastroenterology and Hepatology, vol. 27, no. 9, pp. 1505–1511, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Borrelli, B. Romano, I. Fasolino et al., “Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: Studies in the mouse and human stomach,” Neurogastroenterology & Motility, vol. 24, no. 2, pp. 164–e90, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. L.-S. Liu, J. H. Winston, M. M. Shenoy, G.-Q. Song, J. D. Z. Chen, and P. J. Pasricha, “A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation,” Gastroenterology, vol. 134, no. 7, pp. 2070–2079, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Li and J. D. Z. Chen, “Down-regulation of a-type potassium channel in gastric-specific DRG neurons in a rat model of functional dyspepsia,” Neurogastroenterology & Motility, vol. 26, no. 7, pp. 962–970, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Zhou, S. Li, Y. Wang et al., “Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia,” PLoS ONE, vol. 12, no. 3, Article ID e0174568, 2017. View at Publisher · View at Google Scholar · View at Scopus
  19. L. S. Liu, M. Shenoy, and P. J. Pasricha, “The analgesic effects of the GABAB receptor agonist, baclofen, in a rodent model of functional dyspepsia,” Neurogastroenterology & Motility, vol. 23, no. 4, p. 356, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Liu, Q. Li, R. Sapolsky et al., “Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults,” PLoS ONE, vol. 6, no. 5, Article ID e19498, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. H. Winston, J. E. Aguirre, X.-Z. Shi, and S. K. Sarna, “Impaired Interoception in a Preclinical Model of Functional Dyspepsia,” Digestive Diseases and Sciences, pp. 1–11, 2017. View at Publisher · View at Google Scholar · View at Scopus
  22. J. H. Winston and S. K. Sarna, “Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats,” Gastroenterology, vol. 144, no. 3, pp. 570–e3, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. J. H. Winston and S. K. Sarna, “Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 311, no. 1, pp. G32–G39, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. Q. Li, J. H. Winston, and S. K. Sarna, “Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 310, no. 3, pp. R235–R242, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Tominaga, Y. Fujikawa, F. Tanaka et al., “Structural changes in gastric glial cells and delayed gastric emptying as responses to early life stress and acute adulthood stress in rats,” Life Sciences, vol. 148, pp. 254–259, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Abdel-Aziz, W. Wadie, H. F. Zaki et al., “Novel sequential stress model for functional dyspepsia: efficacy of the herbal preparation STW5,” Phytomedicine, vol. 22, no. 5, pp. 588–595, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Seto, T. Sasaki, K. Katsunuma, N. Kobayashi, K. Tanaka, and J. Tack, “Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats,” Neurogastroenterology & Motility, vol. 20, no. 9, pp. 1051–1059, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Zhang, T. Han, L.-N. Sun et al., “Regulative effects of essential oil from Atractylodes lancea on delayed gastric emptying in stress-induced rats,” Phytomedicine, vol. 15, no. 8, pp. 602–611, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. H. S. Lee, D.-K. Kim, Y. B. Kim, and K. J. Lee, “Effect of acute stress on immune cell counts and the expression of tight junction proteins in the duodenal mucosa of rats,” Gut and Liver, vol. 7, no. 2, pp. 190–196, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Zhang, S. Xie, W. Hu et al., “Effects of electroacupuncture on interstitial cells of cajal (ICC) ultrastructure and connexin 43 protein expression in the gastrointestinal tract of functional dyspepsia (FD) rats,” Medical Science Monitor, vol. 22, pp. 2021–2027, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Wei, X. Li, J. Hao et al., “Proteomic analysis of functional dyspepsia in stressed rats treated with traditional Chinese medicine ‘Wei Kangning’,” Journal of Gastroenterology and Hepatology, vol. 26, no. 9, pp. 1425–1433, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. X.-J. Wang, J.-S. Guo, Y. Xu et al., “Effect of Shuwei Decoction on rats with functional dyspepsia,” Chinese Journal of Integrative Medicine, pp. 1–6, 2016. View at Publisher · View at Google Scholar · View at Scopus
  33. J.-J. Qiu, Z. Liu, P. Zhao et al., “Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model,” World Journal of Gastroenterology, vol. 23, no. 5, pp. 810–816, 2017. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Seto, N. Yoshida, and H. Kaneko, “Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats,” Journal of Pharmacological Sciences, vol. 116, no. 1, pp. 47–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. B. K. Poudel, J. Y. Yu, Y. S. Kwon et al., “The pharmacological effects of benachio-F® on rat gastrointestinal functions,” Biomolecules & Therapeutics, vol. 23, no. 4, pp. 350–356, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Nakata-Fukuda, T. Hirata, Y. Keto, M. Yamano, T. Yokoyama, and Y. Uchiyama, “Inhibitory effect of the selective serotonin 5-HT3 receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats,” European Journal of Pharmacology, vol. 731, no. 1, pp. 88–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Zhou, S. Zhou, J. Gao, G. Zhang, Y. Lu, and C. Owyang, “Upregulation of bile acid receptor TGR5 and nNOS in gastric myenteric plexus is responsible for delayed gastric emptying after chronic high-fat feeding in rats,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 308, no. 10, pp. G863–G873, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Mattsson, Z. Arani, M. Astin, A. Bayati, D. H. Overstreet, and A. Lehmann, “Altered neuroendocrine response and gastric dysmotility in the flinders sensitive line rat,” Neurogastroenterology & Motility, vol. 17, no. 2, pp. 166–174, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. V. Martínez, M. Ryttinger, M. Kjerling, and M. Astin-Nielsen, “Characterisation of colonic accommodation in Wistar Kyoto rats with impaired gastric accommodation,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 376, no. 3, pp. 205–216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Vanormelingen, T. Vanuytsel, T. Masaoka et al., “The normoglycaemic biobreeding rat: a spontaneous model for impaired gastric accommodation,” Gut, vol. 65, no. 1, pp. 73–81, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Asano, T. Tomita, K. Nakamura et al., “Prevalence of gastric motility disorders in patients with functional dyspepsia,” Journal of Neurogastroenterology and Motility, vol. 23, no. 3, pp. 392–399, 2017. View at Publisher · View at Google Scholar
  42. G. Sarnelli, P. Caenepeel, B. Geypens, J. Janssens, and J. Tack, “Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia,” American Journal of Gastroenterology, vol. 98, no. 4, pp. 783–788, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. M. M. Walker and N. J. Talley, “The role of duodenal inflammation in functional dyspepsia,” Journal of Clinical Gastroenterology, vol. 51, no. 1, pp. 12–18, 2017. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Moayyedi, S. Soo, J. Deeks, B. Delaney, M. Innes, and D. Forman, “Pharmacological interventions for non-ulcer dyspepsia,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD001960, 2004. View at Google Scholar · View at Scopus
  45. S. Kindt and J. Tack, “Impaired gastric accommodation and its role in dyspepsia,” Gut, vol. 55, no. 12, pp. 1685–1691, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Carbone and J. Tack, “Gastroduodenal mechanisms underlying functional gastric disorders,” Digestive Diseases, vol. 32, no. 3, pp. 222–229, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. H. Piessevaux, J. Tack, S. Walrand, S. Pauwels, and A. Geubel, “Intragastric distribution of a standardized meal in health and functional dyspepsia: Correlation with specific symptoms,” Neurogastroenterology & Motility, vol. 15, no. 5, pp. 447–455, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Tack, H. Piessevaux, B. Coulie, P. Caenepeel, and J. Janssens, “Role of impaired gastric accommodation to a meal in functional dyspepsia,” Gastroenterology, vol. 115, no. 6, pp. 1346–1352, 1998. View at Publisher · View at Google Scholar · View at Scopus
  49. O. S. Van Boxel, J. J. M. Ter Linde, P. D. Siersema, and A. J. P. M. Smout, “Role of chemical stimulation of the duodenum in dyspeptic symptom generation,” American Journal of Gastroenterology, vol. 105, no. 4, pp. 803–811, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Camilleri and V. Stanghellini, “Current management strategies and emerging treatments for functional dyspepsia,” Nature Reviews Gastroenterology & Hepatology, vol. 10, no. 3, pp. 187–194, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. K. J. Lee and J. Tack, “Duodenal implications in the pathophysiology of functional dyspepsia,” Journal of Neurogastroenterology and Motility, vol. 16, no. 3, pp. 251–257, 2010. View at Publisher · View at Google Scholar
  52. B. Feng, J. H. La, E. S. Schwartz, and G. F. Gebhart, “Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 302, no. 10, pp. G1085–G1098, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. J. M. Rosen, “Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia,” World Journal of Gastrointestinal Pharmacology and Therapeutics, vol. 5, no. 3, p. 122, 2014. View at Publisher · View at Google Scholar
  54. J. Tack, P. Caenepeel, B. Fischler, H. Piessevaux, and J. Janssens, “Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia,” Gastroenterology, vol. 121, no. 3, pp. 526–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. P. Aro, N. J. Talley, S. Johansson, L. Agréus, and J. Ronkainen, “Anxiety is linked to new-onset dyspepsia in the Swedish population: a 10-Year Follow-up Study,” Gastroenterology, vol. 148, no. 5, pp. 928–937, 2015. View at Publisher · View at Google Scholar
  56. I.-S. Lee, H. Wang, Y. Chae, H. Preissl, and P. Enck, “Functional neuroimaging studies in functional dyspepsia patients: a systematic review,” Neurogastroenterology & Motility, vol. 28, no. 6, pp. 793–805, 2016. View at Publisher · View at Google Scholar · View at Scopus
  57. A.-Z. Zhang, Q.-C. Wang, K.-M. Huang et al., “Prevalence of depression and anxiety in patients with chronic digestive system diseases: A multicenter epidemiological study,” World Journal of Gastroenterology, vol. 22, no. 42, pp. 9437–9444, 2016. View at Publisher · View at Google Scholar · View at Scopus
  58. V. M. Smirnov and A. E. Lychkova, “Synergism of sympathetic and parasympathetic systems in the regulation of gastric motility,” Bulletin of Experimental Biology and Medicine, vol. 134, no. 1, pp. 12–14, 2002. View at Publisher · View at Google Scholar
  59. T. J. Ridolfi, W.-D. Tong, T. Takahashi, L. Kosinski, and K. A. Ludwig, “Sympathetic and parasympathetic regulation of rectal motility in rats,” Journal of Gastrointestinal Surgery, vol. 13, no. 11, pp. 2027–2033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. T. Asai, W. W. Mapleson, and I. Power, “Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat,” British Journal of Anaesthesia, vol. 78, no. 3, pp. 301–307, 1997. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Asano, S. Aida, S. Suemasu, K. Tahara, K.-I. Tanaka, and T. Mizushima, “Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia,” Scientific Reports, vol. 5, Article ID 17519, 2015. View at Publisher · View at Google Scholar · View at Scopus
  62. A. E. Bharucha, K. Ravi, and A. R. Zinsmeister, “Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 299, no. 1, pp. G215–G219, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. X. Gao, Y. Zhao, Y. Su et al., “β1/2 or M2/3 receptors are required for different gastrointestinal motility responses induced by acupuncture at heterotopic or homotopic acupoints,” PLoS ONE, vol. 11, no. 12, Article ID e0168200, 2016. View at Publisher · View at Google Scholar · View at Scopus
  64. N. G. Levein, S. E. Thörn, and M. Wattwil, “Dopamine delays gastric emptying and prolongs orocaecal transit time in volunteers,” European Journal of Anaesthesiology, vol. 16, no. 4, pp. 246–250, 1999. View at Publisher · View at Google Scholar · View at Scopus
  65. P. Kashyap, M.-A. Micci, S. Pasricha, and P. J. Pasricha, “The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-Propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying,” Digestive Diseases and Sciences, vol. 54, no. 1, pp. 57–62, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. J. P. Blancquaert, R. A. Lefebvre, and J. L. Willems, “Gastric relaxation by intravenous and intracerebroventricular administration of apomorphine, morphine and fentanyl in the conscious dog,” Arch Int Pharmacodyn Ther, vol. 256, no. 1, pp. 153-154, 1982. View at Google Scholar
  67. M. Nakajima, Y. Shiihara, Y. Shiba et al., “Effect of 5-hydroxytryptamine on gastrointestinal motility in conscious guinea-pigs,” Neurogastroenterology & Motility, vol. 9, no. 4, pp. 205–214, 1997. View at Publisher · View at Google Scholar · View at Scopus
  68. T. K. MacHu, “Therapeutics of 5-HT3 receptor antagonists: current uses and future directions,” Pharmacology & Therapeutics, vol. 130, no. 3, pp. 338–347, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. Y.-S. Jung, M.-Y. Kim, H. S. Lee, S. L. Park, and K. J. Lee, “Effect of DA-9701, a novel prokinetic agent, on stress-induced delayed gastric emptying and hormonal changes in rats,” Neurogastroenterology & Motility, vol. 25, no. 3, pp. 254–e166, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. Y. Taché, V. Martinez, L. Wang, and M. Million, “CRF 1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: Implications for irritable bowel syndrome,” British Journal of Pharmacology, vol. 141, no. 8, pp. 1321–1330, 2004. View at Publisher · View at Google Scholar · View at Scopus
  71. B. Deng, Y. Lin, S. Ma et al., “The leukotriene B4-leukotriene B4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment,” Kidney International, 2016. View at Publisher · View at Google Scholar · View at Scopus
  72. N. A. El-Shitany and B. Eid, “Proanthocyanidin protects against cisplatin-induced oxidative liver damage through inhibition of inflammation and NF-κβ/TLR-4 pathway,” Environmental Toxicology, vol. 32, no. 7, pp. 1952–1963, 2017. View at Publisher · View at Google Scholar · View at Scopus
  73. D. M. Savastano and M. Covasa, “Intestinal nutrients elicit satiation through concomitant activation of CCK1 and 5-HT3 receptors,” Physiology & Behavior, vol. 92, no. 3, pp. 434–442, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. G. Stacher, H. Bergmann, G. Gaupmann et al., “Fat preload delays gastric emptying: reversal by cisapride.,” British Journal of Clinical Pharmacology, vol. 30, no. 6, pp. 839–845, 1990. View at Publisher · View at Google Scholar · View at Scopus
  75. G. Stacher, H. Bergmann, C. Schneider et al., “Effects of the 5‐HT3 receptor antagonist ICS 205‐930 on fat‐delayed gastric emptying and antral motor activity.,” British Journal of Clinical Pharmacology, vol. 30, no. 1, pp. 41–48, 1990. View at Publisher · View at Google Scholar · View at Scopus
  76. K. Tachiyashiki and K. Imaizumi, “Effects of vegetable oils and C18-unsaturated fatty acids on plasma ethanol levels and gastric emptying in ethanol-administered rats,” Journal of Nutritional Science and Vitaminology, vol. 39, no. 2, pp. 163–176, 1993. View at Publisher · View at Google Scholar · View at Scopus
  77. H. Nishio, Y. Hayashi, S. Terashima, and K. Takeuchi, “Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment,” Life Sciences, vol. 79, no. 16, pp. 1523–1530, 2006. View at Publisher · View at Google Scholar · View at Scopus
  78. K. Bielefeldt, N. Ozaki, and G. F. Gebhart, “Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats,” Gastroenterology, vol. 122, no. 3, pp. 752–761, 2002. View at Publisher · View at Google Scholar · View at Scopus
  79. Z. D. Jiang, X. M. Shao, and A. R. Wilkinson, “Changes in BAER amplitudes after perinatal asphyxia during the neonatal period in term infants,” Brain & Development, vol. 28, no. 9, pp. 554–559, 2006. View at Publisher · View at Google Scholar · View at Scopus
  80. Z. D. Jiang, D. M. Brosi, X. M. Shao, and A. R. Wilkinson, “Sustained depression of brainstem auditory electrophysiology during the first months in term infants after perinatal asphyxia,” Clinical Neurophysiology, vol. 119, no. 7, pp. 1496–1505, 2008. View at Publisher · View at Google Scholar · View at Scopus
  81. A. Sarkate and S. S. Dhaneshwar, “Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acidinduced colitis in Wistar rats: Design, kinetics and biological evaluation,” World Journal of Gastroenterology, vol. 23, no. 7, pp. 1147–1162, 2017. View at Publisher · View at Google Scholar · View at Scopus
  82. H. Hoshino, S. Sugiyama, A. Ohara, H. Goto, Y. Tsukamoto, and T. Ozawa, “Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats,” Clinical and Experimental Pharmacology and Physiology, vol. 19, no. 10, pp. 717–722, 1992. View at Publisher · View at Google Scholar · View at Scopus
  83. T. Karaca, Y. H. Uz, S. Demirtas, I. Karaboga, and G. Can, “Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats,” Iranian Journal of Basic Medical Sciences, vol. 18, no. 4, pp. 370–379, 2015. View at Google Scholar · View at Scopus
  84. B. Geeraerts, L. Van Oudenhove, B. Fischler et al., “Influence of abuse history on gastric sensorimotor function in functional dyspepsia,” Neurogastroenterology & Motility, vol. 21, no. 1, pp. 33–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  85. D. K. Chitkara, M. A. L. van Tilburg, N. Blois-Martin, and W. E. Whitehead, “Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review,” American Journal of Gastroenterology, vol. 103, no. 3, pp. 765–774, 2008. View at Publisher · View at Google Scholar · View at Scopus
  86. L. Van Oudenhove, J. Vandenberghe, R. Vos, B. Fischler, K. Demyttenaere, and J. Tack, “Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia,” Psychosomatic Medicine, vol. 73, no. 8, pp. 648–655, 2011. View at Publisher · View at Google Scholar · View at Scopus
  87. Y. Yang, Z. Cheng, H. Tang et al., “Neonatal maternal separation impairs prefrontal cortical myelination and cognitive functions in rats through activation of wnt signaling,” Cerebral Cortex, vol. 27, no. 5, pp. 2871–2884, 2017. View at Publisher · View at Google Scholar
  88. S. Y. Shin, S. H. Han, R.-S. Woo, S. H. Jang, and S. S. Min, “Adolescent mice show anxiety- and aggressive-like behavior and the reduction of long-term potentiation in mossy fiber-CA3 synapses after neonatal maternal separation,” Neuroscience, vol. 316, pp. 221–231, 2016. View at Publisher · View at Google Scholar · View at Scopus
  89. G. A. Carrasco and L. D. Van De Kar, “Neuroendocrine pharmacology of stress,” European Journal of Pharmacology, vol. 463, no. 1-3, pp. 235–272, 2003. View at Publisher · View at Google Scholar · View at Scopus
  90. V. Martinez, L. Wang, M. Million, J. Rivier, and Y. Taché, “Urocortins and the regulation of gastrointestinal motor function and visceral pain,” Peptides, vol. 25, no. 10, pp. 1733–1744, 2004. View at Publisher · View at Google Scholar · View at Scopus
  91. Y. Nakade, D. Tsuchida, H. Fukuda, M. Iwa, T. N. Pappas, and T. Takahashi, “Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 288, no. 2, pp. R427–R432, 2005. View at Publisher · View at Google Scholar · View at Scopus
  92. H. Taniguchi, H. Ariga, J. Zheng et al., “Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 295, no. 2, pp. G403–G411, 2008. View at Publisher · View at Google Scholar · View at Scopus
  93. T. Nozu, S. Kumei, K. Takakusaki, and T. Okumura, “Water-avoidance stress enhances gastric contractions in freely moving conscious rats: Role of peripheral CRF receptors,” Journal of Gastroenterology, vol. 49, no. 5, pp. 799–805, 2014. View at Publisher · View at Google Scholar · View at Scopus
  94. J. Zheng, A. Dobner, R. Babygirija, K. Ludwig, and T. Takahashi, “Effects of repeated restraint stress on gastric motility in rats,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 296, no. 5, pp. R1358–R1365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  95. P. R. Saunders, U. Kosecka, D. M. McKay, and M. H. Perdue, “Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine,” American Journal of Physiology, vol. 267, no. 5, pp. G794–G799, 1994. View at Google Scholar · View at Scopus
  96. J. E. Kellow, P. M. Langeluddecke, G. M. Eckersley, M. P. Jones, and C. C. Tennant, “Effects of acute psychologic stress on small-intestinal motility in health and the irritable bowel syndrome,” Scandinavian Journal of Gastroenterology, vol. 27, no. 1, pp. 53–58, 1992. View at Publisher · View at Google Scholar · View at Scopus
  97. J. Li, Y. Li, B. Zhang, X. Shen, and H. Zhao, “Why depression and pain often coexist and mutually reinforce: Role of the lateral habenula,” Experimental Neurology, vol. 284, pp. 106–113, 2016. View at Publisher · View at Google Scholar · View at Scopus
  98. J. Vandenberghe, R. Vos, P. Persoons, K. Demyttenaere, J. Janssens, and J. Tack, “Dyspeptic patients with visceral hypersensitivity: sensitisation of pain specific or multimodal pathways?” Gut, vol. 54, no. 7, pp. 914–919, 2005. View at Publisher · View at Google Scholar · View at Scopus
  99. F. O. The, G. E. Boeckxstaens, S. A. Snoek et al., “Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice,” Gastroenterology, vol. 133, no. 4, pp. 1219–1228, 2007. View at Publisher · View at Google Scholar · View at Scopus
  100. G. E. Boeckxstaens and W. J. de Jonge, “Neuroimmune mechanisms in postoperative ileus,” Gut, vol. 58, no. 9, pp. 1300–1311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Ishii, H. Kusunoki, N. Manabe et al., “Evaluation of duodenal hypersensitivity induced by duodenal acidification using transnasal endoscopy,” Journal of Gastroenterology and Hepatology, vol. 25, no. 5, pp. 913–918, 2010. View at Publisher · View at Google Scholar · View at Scopus
  102. K. Lee, “Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans,” The American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 286, no. 2, pp. 278G–284, 2004. View at Publisher · View at Google Scholar
  103. A. N. Pilichiewicz, K. L. Feltrin, M. Horowitz et al., “Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY,” American Journal of Gastroenterology, vol. 103, no. 10, pp. 2613–2623, 2008. View at Publisher · View at Google Scholar · View at Scopus
  104. N. A. M. Van Ooteghem, M. Samsom, K. J. Van Erpecum, and G. P. Van Berge-Henegouwen, “Effects of ileal bile salts on fasting small intestinal and gallbladder motility,” Neurogastroenterology & Motility, vol. 14, no. 5, pp. 527–533, 2002. View at Publisher · View at Google Scholar · View at Scopus
  105. D. H. Overstreet, “The flinders sensitive line rats: a genetic animal model of depression,” Neuroscience & Biobehavioral Reviews, vol. 17, no. 1, pp. 51–68, 1993. View at Publisher · View at Google Scholar · View at Scopus
  106. D. H. Overstreet, O. Pucilowski, A. H. Rezvani, and D. S. Janowsky, “Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression,” Psychopharmacology, vol. 121, no. 1, pp. 27–37, 1995. View at Publisher · View at Google Scholar · View at Scopus
  107. D. H. Overstreet, “Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists,” Behavior Genetics, vol. 32, no. 5, pp. 335–348, 2002. View at Publisher · View at Google Scholar · View at Scopus
  108. W. P. Paré, “The performance of WKY rats on three tests of emotional behavior,” Physiology & Behavior, vol. 51, no. 5, pp. 1051–1056, 1992. View at Publisher · View at Google Scholar · View at Scopus
  109. M. Astin Nielsen, A. Bayati, and H. Mattsson, “Wistar Kyoto rats have impaired gastric accommodation compared to sprague dawley rats due to increased gastric vagal cholinergic tone,” Scandinavian Journal of Gastroenterology, vol. 41, no. 7, pp. 773–781, 2006. View at Publisher · View at Google Scholar · View at Scopus
  110. B. E. Lacy, K. T. Weiser, A. T. Kennedy, M. D. Crowell, and N. J. Talley, “Functional dyspepsia: the economic impact to patients,” Alimentary Pharmacology & Therapeutics, vol. 38, no. 2, pp. 170–177, 2013. View at Publisher · View at Google Scholar · View at Scopus