Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry
Table 2
Clinical characteristics of cirrhosis patients admitted with HN subdivided by hyponatremia severity.
Total N = 518
[Na+], mmol/L
<120 n = 106
≥120–≤125 n = 202
>125–≤130 n = 210
Median age, y
56
54
56
57
Male/female, n
345/173
73/33
130/72
142/68
BUN, mg/dL
20.0 (19.0)
18.0 (20.5)
21.0 (20.0)
19.0 (17.0)
Cr, mg/dL
1.0 (0.6)
1.0 (0.7)
1.1 (0.7)
1.0 (0.6)
BUN:Cr ratio
18.9 (10.4)
19.0 (12.0)
19.8 (11.6)
18.0 (9.1)
Alb, g/dL
2.5 (0.8)
2.6 (1.1)
2.5 (0.8)
2.4 (0.6)
Tbili, µmol/L
4.3 (7.4)
4.3 (7.2)
4.5 (6.9)
4.3 (7.6)
INR, s
1.7 (0.6)
1.6 (0.5)
1.7 (0.7)
1.7 (0.7)
Severe ascites, n (%)
284 (55)
53 (50)
124 (61)
107 (51)
Severe HE, n (%
116 (22)
30 (28)
51 (25)
35 (17)
C-P score
11.0 (3.0)
10.5 (3.0)
11.0 (3.0)
10.0 (3.0)
MELD score
20.2 (9.7)
18.7 (9.0)
20.8 (8.0)
20.2 (10.4)
MELD-Na score
27.3 (6.3)
26.7 (5.6)
28.0 (5.0)
26.3 (7.6)
< 0.01. Values for blood urea nitrogen (BUN), creatinine (Cr), BUN:Cr ratio, albumin (Alb), total bilirubin (Tbili), international normalized ratio (INR), and Child-Pugh (CP), Model for End-Stage Liver Disease (MELD), and MELD-NA scores are median (interquartile range). HE, hepatic encephalopathy; HN, hyponatremia.
