48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse

Table 2

Independent variables associated with virologic relapse in GEE models.

Parameters	Univariate		Multivariate
	OR (95% CI)		OR (95% CI)
Sex
Male	Ref	-	Ref	-
Female	1.12 (0.51–2.49)	0.774	1.14 (0.59–2.19)	0.704
Age, year	1.05 (1.01–1.08)	0.009	1.06 (1.02–1.10)	0.003
BMI, kg/m^2	0.97 (0.87–1.09)	0.617	0.85 (0.75–0.95)	0.006
Duration of NA treatment, year	0.89 (0.74–1.08)	0.255	1.40 (1.14–1.73)	0.001
Duration of negative HBV DNA maintenance, year	0.81 (0.65–1.01)	0.066	0.52 (0.33–0.83)	0.005
HBsAg, (IU/mL)	1.79 (1.32–2.45)	<0.001	2.21 (1.47–3.32)	<0.001
Origin HBeAg
Negative	Ref	-	Ref	-
Positive	0.38 (0.19–0.79)	0.010	0.32 (0.14–0.74)	0.008