Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure

Table 2

Human hepatocyte transplantation for patients with acute liver failure.

Indication	Patient Age	Number of viable cells transplanted	Outcome	Study/Ref
Drug-induced acute liver failure	27 years	2.8x10^7	OLT after 10 days	[24]
	26 years	2.8x10^7	OLT after 2 days	[33]
	32 years	1.3x10^9	Death on day 14	[34]
	35 years	1.0x10^10	Death on day 20
	55 years	3.9x10^10	Death in 6 hours
	27 years	3.0x10^7	OLT on day 10	[35]
	26 years	1.2x10^9	OLT on day 2
	21 years	9.4x10^8	Death on day 1
	35 years	5.4x10^9	Death on day 18
	35 years	3.7x10^9	Full recovered after; OLT
	51 years	3.9x10^9	OLT on day 3
Viral-induced acute liver failure	28 years	1.9x10^7	OLT on day 3	[24]
	28 years	1.7x10^8	OLT on day 3	[33]
	37 years	1.2x10^8	Death on day 5
	43 years	7.3x10^8	OLT on day 1
	37 years	8.8x10^8	Full recovered no OLT	[36]
	29 years	1.0x10^10	Death in 18 hours	[34]
	65 years	3.0x10^10	Death on day 52
	4 years	3.4x10^9	Death on day 2	[35]
	54 years	6.6x10^9	Death on day 7
Idiopathic acute liver failure	3.5 months	1.8x10^10	OLT on day 1	[35]
Retransplantation	42 years; 49 years	2,209 × 10^6 hepatocytes given in 4 infusions	death on day 10; alive, liver retransplantation on day 6	[37]
Acute-on-chronic liver failure	7 patients with mean age, 35.7 years	(4.2 - 6.0) x 10^6	3 patients fully recovered; from liver failure, 1 survived and subsequently underwent OLT, and the remaining 3 patients; died between 2.5 and 12 months hepatocyte transplantation	[38]