Transient Elastography for Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis B: A Meta-Analysis
Table 1
Characteristics of the included studies.
Author
Study type
Year
HIV/HBV
METAVIR
Biopsy size
Biopsy to TE time (days)
Sample
Prevalence F2–F4
Prevalence F4
TE cut-off
AUROC
Cao et al.
Prospective
2014
NO
YES
>=15 mm and >=6 portal tracts
NA
162
0.61
0.12
7.3/17.5
NA/NA
Cardoso et al.
Retrospective
2011
NO
YES
>=15 mm and/or >=6 portal tracts
1
202
0.421
0.079
7.2/11
0.867/0.935
Castéra et al.
Prospective
2010
NO
YES
>=16 mm
NA
60
0.73
0.25
7.1/9.6
0.76/0.89
Chan et al.
Prospective
2009
NO
YES
>=15 mm and >=6 portal tracts
28
136
NA
0.25
NA/9
NA/0.93
Chen et al.
Retrospective
2011
NO
YES
>=15 mm
7
213
0.479
0.15
7.0/13.0
0.916/0.971
Chen et al.
Prospective
2012
NO
YES
>=15 mm and >=10 portal tracts
7
315
0.771
0.235
NA/10.4
NA/0.88
Cheng et al.
Prospective
2015
NO
YES
>=10 mm and >=8 portal tracts
1
459
0.61
0.152
7.2/18.2
0.82/0.87
Cheng et al.
Prospective
2014
NO
NO
>=15 mm and >=6 portal tracts
1
99
0.54
NA
8.15/NA
0.896/NA
Cho et al.
Prospective
2011
NO
YES
>=15 mm
1
121
0.727
0.074
7.8/14.0
0.849/0.867
Degos et al.
Prospective
2010
NO
YES
>=18 mm
1
284
0.415
0.102
5.2/12.9
0.78/0.90
Dong et al.
Prospective
2015
NO
NO
>=15 mm and >=6 portal tracts
NA
81
0.604
0.098
10.3/9.4
0.753/0.873
Gaia et al.
Prospective
2011
NO
YES
>=20 mm
120
70
0.53
0.31
7.2/10.6
0.674/0.763
Goyal et al.
Prospective
2013
NO
YES
>=15 mm and >=6 portal tracts
38
357
0.792
0.059
6.0/11.0
0.84/0.93
Huang et al.
Prospective
2016
NO
NO
>=15 mm
NA
263
0.148
0.011
8/NA
0.911/NA
Jia et al.
Prospective
2015
NO
YES
>=10 mm and >=8 portal tracts
NA
469
0.612
0.122
7.3/10.7
0.82/0.90
Kim et al. 1
Prospective
2012
NO
NO
>=20 mm
1
194
0.845
0.387
8.8/14.1
0.873/0.910
Kim et al. 2
Prospective
2012
NO
YES
>=20 mm
1
170
0.712
0.276
8.0/14.0
0.937/0.963
Kim et al.
Prospective
2009
NO
YES
>=10 mm and >=10 portal tracts
1
91
NA
0.692
NA/10.3
NA/0.803
Kim et al. 1
Prospective
2009
NO
YES
>=6 portal tracts
1
130
0.923
0.515
NA/10.1
NA/0.840
Kim et al. 2
Prospective
2009
NO
YES
>=15 mm
NA
91
0.868
0.396
NA/NA
0.837/0.913
Kim et al. 3
Prospective
2012
NO
NO
>=15 mm
1
150
0.847
0.453
6.0/9.4
NA/NA
Lesmana et al.
Retrospective
2011
NO
YES
>=15 mm and >=5 portal tracts
1
117
0.624
NA
5.85/NA
0.614/NA
liu et al.
Prospective
2015
NO
NO
>=8 portal tracts
NA
115
0.53
0.15
8.50/11.75
0.838/0.914
Liu et al.
Prospective
2012
NO
NO
>=10 mm
NA
134
0.43
0.11
7.60/13.20
0.93/0.96
Marcellin et al.
Prospective
2009
NO
YES
>=6 portal tracts
1
173
0.503
0.081
7.2/11.0
0.81/0.93
Meng et al.
Prospective
2015
NO
YES
>=12 mm and >=6 portal tracts
2
287
0.488
0.157
8.85/17.05
0.909/0.815
Meng et al.
Prospective
2016
NO
NO
>=15 mm
7
168
NA
0.15
15.1
0.927
Miailhes et al.
Prospective
2011
YES
YES
>=10 mm
3
59
0.61
0.203
5.9/9.4
0.85/0.96
Osakabe et al.
Prospective
2011
NO
YES
>=15 mm and >=8 portal tracts
30
51
0.882
0.275
7.1/16.0
0.844/0.93
Qin et al.
Prospective
2015
NO
NO
NA
1
152
0.68
0.07
8.2/13.1
0.752/0.973
Seo et al.
Retrospective
2015
NO
NO
>=15 mm
90
567
0.72
0.2
7.8/11.6
0.774/0.902
Sporea et al.
Prospective
2010
NO
YES
>=20 mm and >=8 portal tracts
NA
140
0.764
0.05
7/13.6
0.658/0.974
Stibbe et al.
Prospective
2011
NO
YES
>=20 mm
NA
48
0.458
0.104
7.0/14.0
NA/0.89
Trembling et al.
Prospective
2013
NO
YES
>=20 mm
1
182
0.626
0.198
NA/11.85
NA/O.95
Vigano et al.
Prospective
2011
NO
YES
>=20 mm
NA
125
0.53
0.16
6.2/13.1
NA/NA
Wang et al.
Prospective
2015
NO
NO
>=15 mm and >=6 portal tracts
NA
142
0.585
0.092
8.15/13.95
0.897/0.968
Wang et al.
Prospective
2014
NO
NO
>=15 mm
NA
80
0.7
0.1125
7.3/12.4
0.865/0.944
Wang et al.
Prospective
2016
NO
NO
NA
NA
127
0.76
0.24
NA/15.2
NA/0.805
Wong et al.
Prospective
2009
NO
YES
>=15 mm and >=6 portal tracts
NA
134
0.78
0.24
NA/13.4
NA/0.89
Wong et al. Tr-c
Prospective
2014
NO
YES
>=15 mm and >=6 portal tracts
NA
238
0.693
0.235
NA/10
NA/0.9
Wong et al. Va-c
Prospective
2014
NO
YES
>=15 mm and >=6 portal tracts
NA
85
0.565
0.259
NA/10
NA/0.87
Zhang et al.
Prospective
2016
NO
NO
>=22 mm
7
180
0.72
0.18
7.5/10.6
0.813/0.799
Zhang et al.
Prospective
2016
NO
NO
>=15 mm
NA
124
0.54
NA
6.95
0.732
Zhang et al.
Prospective
2011
NO
NO
>=15 mm and >=6 portal tracts
NA
88
0.671
0.159
7.25/12.40
0.857/0/948
Zhu et al.
Prospective
2011
NO
YES
>=15 mm and >=6 portal tracts
1
175
NA
0.166
7.9/13.8
NA/0.98
AUROC, area under the receiver-operating curve; TE, transient elastography; HIV/HBV, hepatitis B and HIV-coinfected patients; METAVIR, liver biopsy assessed according to METAVIR or not; TE cut-off, TE cut-off used to predict; NA, data not available.
