Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Gastroenterology and Hepatology
Volume 2018, Article ID 3870454, 9 pages
https://doi.org/10.1155/2018/3870454
Research Article

Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children

1Department of Pediatrics, Gastroenterology and Allergology, Medical University of Białystok, Białystok, Poland
2Department of Radiology, Medical University of Białystok, Białystok, Poland
3Department of Radiology, University Children Hospital, Białystok, Poland
4Łomża State University of Applied Sciences, Łomża, Poland

Correspondence should be addressed to Marta Flisiak-Jackiewicz; lp.po@kaisilf_m

Received 3 February 2018; Accepted 5 April 2018; Published 26 April 2018

Academic Editor: Peter Jarčuška

Copyright © 2018 Marta Flisiak-Jackiewicz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Alisi, G. Carpino, and V. Nobili, “Paediatric nonalcoholic fatty liver disease,” Current Opinion in Gastroenterology, vol. 29, no. 3, pp. 279–284, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Della Corte, A. Alisi, A. Saccari, R. De Vito, A. Vania, and V. Nobili, “Nonalcoholic fatty liver in children and adolescents: An overview,” Journal of Adolescent Health, vol. 51, no. 4, pp. 305–312, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Masarone, A. Federico, L. Abenavoli, C. Loguercio, and M. Persico, “Non alcoholic fatty liver: epidemiology and natural history,” Reviews on Recent Clinical Trials, vol. 9, no. 3, pp. 126–133, 2014. View at Google Scholar · View at Scopus
  4. E. M. Brunt, “Histopathology of nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 16, no. 42, pp. 5286–5296, 2010. View at Publisher · View at Google Scholar
  5. V. Nobili, G. Bedogni, R. Berni Canani et al., “The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?” Pediatric Obesity, vol. 7, no. 6, pp. e75–e80, 2012. View at Publisher · View at Google Scholar
  6. J. B. Moore, “Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome,” Proceedings of the Nutrition Society, vol. 69, pp. 211–220, 2010. View at Publisher · View at Google Scholar
  7. Z. Tariq, C. J. Green, and L. Hodson, “Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?” Liver International, vol. 34, no. 7, pp. e180–e190, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Basaranoglu, G. Basaranoglu, and H. Sentürk, “From fatty liver to fibrosis: a tale of ‘second hit’,” World Journal of Gastroenterology, vol. 19, no. 8, pp. 1158–1165, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Festi, R. Schiumerini, L. H. Eusebi, G. Marasco, M. Taddia, and A. Colecchia, “Gut microbiota and metabolic syndrome,” World Journal of Gastroenterology, vol. 20, no. 43, pp. 16079–16094, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Ferolla, G. Armiliato, C. Couto, and T. Ferrari, “The role of intestinal bacteria overgrowth in obesity-related nonalcoholic fatty liver disease,” Nutrients, vol. 6, no. 12, pp. 5583–5599, 2014. View at Publisher · View at Google Scholar
  11. J. M. Lotowska, M. E. Sobaniec-Lotowska, S. B. Bockowska, and D. M. Lebensztejn, “Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria,” World Journal of Gastroenterology, vol. 20, no. 15, pp. 4335–4340, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. R. S. Rector, J. P. Thyfault, G. M. Uptergrove et al., “Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model,” Journal of Hepatology, vol. 52, no. 5, pp. 727–736, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. E. Nelson, H. Klintworth, and K. V. Kowdley, “Iron metabolism in Nonalcoholic Fatty Liver Disease,” Current Fungal Infection Reports, vol. 14, no. 1, pp. 8–16, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Demircioğlu, G. Görünmez, E. Dağıstan et al., “Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study,” European Journal of Pediatrics, vol. 173, no. 7, pp. 947–951, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M. F. Abdelmalek, A. Suzuki, C. Guy et al., “Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease,” Hepatology, vol. 51, no. 6, pp. 1961–1971, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Xu, G. T. Barnes, Q. Yang et al., “Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance,” The Journal of Clinical Investigation, vol. 112, no. 12, pp. 1821–1830, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Tilg and A. R. Moschen, “Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis,” Hepatology, vol. 52, no. 5, pp. 1836–1846, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R. De Vito, A. Alisi, A. Masotti, S. Ceccarelli, N. Panera, A. Citti et al., “Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease,” International Journal of Molecular Medicine, vol. 30, pp. 49–56, 2012. View at Publisher · View at Google Scholar
  19. M. Asrih and F. R. Jornayvaz, “Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance,” Journal of Endocrinology, vol. 218, no. 3, pp. R25–R36, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Stojsavljevic, M. Gomerčić Palčić, L. Virović Jukić, L. Smirčić Duvnjak, and M. Duvnjak, “Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 20, no. 48, pp. 18070–18091, 2014. View at Publisher · View at Google Scholar
  21. H. Tilg, “The role of cytokines in non-alcoholic fatty liver disease,” Digestive Diseases, vol. 28, no. 1, pp. 179–185, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Crespo, S. Lappe, A. E. Feldstein, and N. Alkhouri, “Similarities and differences between pediatric and adult nonalcoholic fatty liver disease,” Metabolism - Clinical and Experimental, vol. 65, no. 8, pp. 1161–1171, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. C. A. Dinarello, “Interleukin-18 and the pathogenesis of inflammatory diseases,” Seminars in Nephrology, vol. 27, no. 1, pp. 98–114, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Skurk, H. Kolb, S. Müller-Scholze, K. Röhrig, H. Hauner, and C. Herder, “The proatherogenic cytokine interleukin-18 is secreted by human adipocytes,” European Journal of Endocrinology, vol. 152, no. 6, pp. 863–868, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Gracie, S. E. Robertson, and I. B. McInnes, “Interleukin-18,” Journal of Leukocyte Biology, vol. 73, no. 2, pp. 213–224, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. C. A. Dinarello, D. Novick, S. Kim, and G. Kaplanski, “Interleukin-18 and IL-18 binding protein,” Frontiers in Immunology, vol. 4, Article ID Article 289, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Trøseid, I. Seljeflot, and H. Arnesen, “The role of interleukin-18 in the metabolic syndrome,” Cardiovascular Diabetology, vol. 9, article no. 11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. G. P. Van Guilder, G. L. Hoetzer, J. J. Greiner, B. L. Stauffer, and C. A. DeSouza, “Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults,” Obesity, vol. 14, no. 12, pp. 2127–2131, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. C. P. Fischer, L. B. Perstrup, A. Berntsen, P. Eskildsen, and B. K. Pedersen, “Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans,” Clinical Immunology, vol. 117, no. 2, pp. 152–160, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Trøseid, I. Seljeflot, E. M. Hjerkinn, and H. Arnesen, “Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome synergistic effect of inflammation and hyperglycemia,” Diabetes Care, vol. 32, no. 3, pp. 486–492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. O. Ludwiczek, A. Kaser, D. Novick et al., “Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease,” Journal of Clinical Immunology, vol. 22, no. 6, pp. 331–337, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. A. López-Bermejo, M. Bosch, M. Recasens et al., “Potential role of interleukin-18 in liver disease associated with insulin resistance,” Obesity Research, vol. 13, no. 11, pp. 1925–1931, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Vecchiet, K. Falasca, P. Cacciatore et al., “Association between plasma interleukin-18 levels and liver injury in chronic hepatitis C virus infection and non-alcoholic fatty liver disease,” Annals of Clinical & Laboratory Science, vol. 35, no. 4, pp. 415–422, 2005. View at Google Scholar · View at Scopus
  34. J. J. Reilly, “Diagnostic accuracy of the BMI for age in paediatrics,” International Journal of Obesity, vol. 30, no. 4, pp. 595–597, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Publisher · View at Google Scholar · View at Scopus
  36. S. H. Saverymuttu, A. E. A. Joseph, and J. D. Maxwell, “Ultrasound scanning in the detection of hepatic fibrosis and steatosis,” British Medical Journal, vol. 292, no. 6512, pp. 13–15, 1986. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Tarasów, L. Siergiejczyk, A. Panasiuk et al., “MR proton spectroscopy in liver examinations of healthy individuals in vivo,” Medical Science Monitor, vol. 8, no. 2, pp. MT36–MT40, 2002. View at Google Scholar · View at Scopus
  38. S. Tapan, T. Dogru, M. Kara et al., “Circulating levels of interleukin-18 in patients with non-alcoholic fatty liver disease,” Scandinavian Journal of Clinical & Laboratory Investigation, vol. 70, no. 6, pp. 399–403, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. M. D. Beaton, S. Chakrabarti, and P. C. Adams, “Inflammation is not the cause of an elevated serum Ferritin in non-alcoholic fatty liver disease,” Annals of Hepatology, vol. 13, no. 3, pp. 353–356, 2014. View at Google Scholar · View at Scopus
  40. K. V. Kowdley, P. Belt, L. A. Wilson et al., “Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease,” Hepatology, vol. 55, no. 1, pp. 77–85, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Licata, M. E. Nebbia, G. Cabibbo et al., “Hyperferritinemia is a risk factor for steatosis in chronic liver disease,” World Journal of Gastroenterology, vol. 15, no. 17, pp. 2132–2138, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. J. H. Na, S. W. Park, Y. Kang, H. Koh, and S. Kim, “The clinical significance of serum ferritin in pediatric non-alcoholic fatty liver disease,” Pediatric Gastroenterology, Hepatology and Nutrition, vol. 17, no. 4, pp. 248–256, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Kitsios, M. Papadopoulou, K. Kosta, N. Kadoglou, M. Papagianni, and K. Tsiroukidou, “High-sensitivity C-reactive protein levels and metabolic disorders in obese and overweight children and adolescents,” Journal of Clinical Research in Pediatric Endocrinology, vol. 5, no. 1, pp. 44–49, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. N. F. Schwenzer, F. Springer, C. Schraml, N. Stefan, J. Machann, and F. Schick, “Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance,” Journal of Hepatology, vol. 51, no. 3, pp. 433–445, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Vajro, S. Lenta, P. Socha et al., “Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN hepatology committee,” Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 5, pp. 700–713, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. E. A. Roberts, “Pediatric nonalcoholic fatty liver disease (NAFLD): A "growing" problem?” Journal of Hepatology, vol. 46, no. 6, pp. 1133–1142, 2007. View at Publisher · View at Google Scholar · View at Scopus