Research Article
Notch Signaling Pathway Is Inhibited in the Development of Barrett’s Esophagus: An In Vivo and In Vitro Study
Figure 8
Effects of Notch signaling inhibition. Expressions of Notch1, Hes1, and K13 were significantly downregulated in cells transfected with Notch1-siRNA, in concert with significant increase of MUC2 expression. (a) Notch1, Hes1, K13, and MUC2 mRNA expression levels by RT-qPCR in Het-1A cells transfected with Notch1-siRNA. , statistically significant difference. , statistically significant difference. (b) Notch1, Hes1, K13, and MUC2 protein expressions by western blot analysis in Het-1A cells after Notch signaling inhibition by Notch1-siRNA.
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