β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC

Figure 5

(a) Interleukin-17A mRNA. CNRQ = Calibrated Normalized Relative Quantities, normalized to mean of all samples. Total patients studied = 65 with Normal group: thirteen (13) patients, C-IBS group: eighteen (18) patients, D-IBS group: six (6) patients, CD group: six (6) patients, UC group: six (6) patients, and CRC group: sixteen (16) patients. (b) PPARγ mRNA expression. Total patient number studied = seventy-four (74) with Normal group: fifteen (15) patients, C-IBS group: twenty-two (22) patients, D-IBS group: eight (8) patients, CD group: six (6) patients, UC group: seven (7) patients, and CRC group: sixteen (16) patients. denotes significantly different versus normal group (p<0.05).

(a) IL-17A mRNA expression was significantly reduced in IBS and unchanged in CRC and IBD

(b) PPARgamma was significantly increased in IBS and unchanged in IBD and CRC