Pathological Features of Mitochondrial Ultrastructure Predict Susceptibility to Post-TIPS Hepatic Encephalopathy

Figure 2

Mitochondrial ultrastructure at 5 different damage levels according to the Flameng classification system. A1: Level 0 (score 0) mitochondrial structure is normal and full of substrate particles (white arrow). A2: Level 1 (score 1) mitochondrial structure is essentially normal with a lack of substrate particles (white arrow). A3: Level 2 (score 2) mitochondria are markedly swollen with transparent substrate (white arrow). A4: Level 3 (score 3) mitochondrial crest is divided with transparent or thick substrate (white arrow). A5: Level 4 (score 4) mitochondria are vacuolated with divided crest, and substrate and membrane integrity have disappeared (white arrow). A6: microcellular ultrastructure vision obtained more mitochondrial structure.