Research Article
Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma
Table 3
Association between clinicopathological variables and expression of alpha-fetoprotein in hepatocellular carcinoma.
| | Variables | Alfa-fetoprotein in HCC | Total | P value | EpCAM in HCC | Total | P value | | Negative | Positive | Negative | Positive |
| | Etiology | | | | | | | | | | Idiopathic | 6 (85.71%) | 1 (14.29%) | 7 (100.0%) | | 6 (85.71%) | 1 (14.29%) | 7 (100.0%) | | | Ethanol | 3 (60.00%) | 2 (40.00%) | 5 (100.0%) | 0.703 | 4 (80.00%) | 1 (20.00%) | 5 (100.0%) | 0.673 | | Virus B | 8 (66.67%) | 4 (33.33%) | 12 (100.0%) | | 7 (58.33%) | 5 (41.67%) | 12 (100.0%) | | | Virus C | 12 (70.59%) | 5 (29.11%) | 17 (100.0%) | | 12 (70.59%) | 5 (29.41%) | 17 (100.0%) | |
| | Node | | | | | | | | | | Single node | 23 (71.88%) | 9 (28.12%) | 32 (100.0%) | 0.999 | 22 (68.75%) | 10 (31.25%) | 32 (100.0%) | 0.702 | | Multiple | 6 (66.67%) | 3 (33.33%) | 9 (100.0%) | | 7 (77.78%) | 2 (22.22%) | 9 (100.0%) | |
| | Diameter | | | | | | | | | | ≤ 5 cm | 14 (60.87%) | 9 (39.13%) | 23 (100.0%) | 0.171 | 13 (56.52%) | 10 (43.48%) | 23 (100.0%) | 0.038 | | > 5 cm | 15 (83.33%) | 3 (16.67%) | 18 (100.0%) | | 16 (88.89%) | 2 (11.11%) | 18 (100.0%) | |
| | TNM Staging | | | | | | | | | | I | 15 (83.33%) | 3 (16.67%) | 18 (100.0%) | | 13 (72.22%) | 5 (27.78%) | 18 (100.0%) | | | II | 11 (64.71%) | 6 (35.29%) | 17 (100.0%) | 0.241 | 11 (64.71%) | 6 (35.29%) | 17 (100.0%) | 0.728 | | III | 3 (50.00%) | 3 (50.00%) | 6 (100.0%) | | 5 (83.33%) | 1 (29.27%) | 6 (100.0%) | |
| | Angiolymphatic invasion | | | | | | | | | | No | 20 (83.33%) | 4 (16.67%) | 24 (100.0%) | 0.045 | 18 (75.00%) | 6 (25.00%) | 24 (100.0%) | 0.507 | | Yes | 9 (52.94%) | 8 (47.06%) | 17 (100.0%) | | 11 (64.71%) | 6 (35.29%) | 17 (100.0%) | |
| | Degree of histological differentiation | | | | | | | | | | Well | 15 (78.95%) | 4 (21.05%) | 19 (100.0%) | 0.492 | 16 (84.21%) | 3 (15.79%) | 19 (100.0%) | 0.182 | | Moderate | 11 (61.11%) | 7 (38.89%) | 18 (100.0%) | | 11 (61.11%) | 7 (38.89%) | 18 (100.0%) | | | Poor | 3 (75.00%) | 1 (25.00%) | 1 (100.0%) | | 2 (50.00%) | 2 (50.00%) | 4 (100.0%) | |
| | Serum alfa-fetoprotein (ng / mL) | | | | | | | | | | Up to 100 | 23 (88.46%) | 3 (11.53%) | 26 (100.0%) | 0.003 | 21 (80.76%) | 5 (19.24%) | 26 (100.0%) | 0.006 | | 100 a 400 | 3 (42.85%) | 4 (57.14%) | 7 (100.0%) | | 5 (71.42%) | 2 (28.58%) | 7 (100.0%) | | | > 400 | 3 (37.5%) | 5 (62.50%) | 8 (100.0%) | | 3 (37.50%) | 5 (62.50%) | 8 (100.0%) | |
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: statistical significance by Fisher’s exact test. |
