Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy
Table 3
Summary of Cox-regression analyses of the prognostic factors for 3-year overall survival ( = 121).
Variables
Univariate
Multivariate
HR (95% CI)
HR (95% CI)
Gender
0.561
0.537
Male
Ref
Ref
Female
0.84 (0.46–1.53)
0.82 (0.43–1.55)
Age
0.006
0.015
<55
Ref
Ref
≥55
0.52 (0.33–0.83)
0.51 (0.29–0.87)
T stage
0.020
0.162
T1-2
Ref
Ref
T3-4
1.91 (1.11–3.29)
1.56 (0.84–2.91)
N stage
0.006
0.027
N0
Ref
-
Ref
-
N1
2.43 (1.33–4.41)
0.004
2.14 (1.14–3.99)
0.017
N2-3
2.37 (1.31–4.29)
0.004
2.31 (1.18–4.51)
0.014
Location
0.017
0.080
Cervical and superior thoracic
Ref
-
Ref
-
Middle thoracic
0.46 (0.27–0.79)
0.004
0.50 (0.27–0.92)
0.025
Inferior thoracic
0.54 (0.26–1.10)
0.091
0.58 (0.27–1.27)
0.175
Pathology
0.285
0.103
High differentiation
Ref
-
Ref
-
Middle differentiation
0.81 (0.45–1.46)
0.485
1.18 (0.61–2.29)
0.624
Low differentiation
1.26 (0.71–2.23)
0.425
1.89 (1.00–3.60)
0.051
Pretreatment weight loss
<0.001
0.027
Pre-LWL
Ref
Ref
Pre-HWL
2.37 (1.46–3.86)
1.89 (1.07–3.32)
Weight loss
0.305
0.497
LWL
Ref
Ref
HWL
0.76 (0.45–1.28)
1.30 (0.61–2.75)
BMI
0.011
0.545
UW
Ref
-
Ref
-
NW
0.38 (0.19–0.73)
0.004
0.61 (0.25–1.48)
0.275
OW
0.36 (0.16–0.80)
0.013
0.61 (0.22–1.73)
0.352
Pre-LWL, low pretreatment weight loss; pre-HWL, high pretreatment weight loss; LWL, low weight loss during treatment; HWL, high weight loss during treatment; UW, underweight; NW, normal weight; OW, overweight; BMI, body mass index; HR, hazard ratio; CI, confidence interval.
