Research Article
Glucose Metabolism Changes in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals
Table 2
Baseline laboratory parameters and DAA treatment parameters by degree of fibrosis.
| | | F0-F2
N=118
Absolute (relative)
counts or mean ± SEM | F3
N=80
Absolute (relative)
counts or mean ± SEM | F4
N=170
Absolute (relative)
counts or mean ± SEM | P |
| | HCV RNA IU/mL | 2 945 961±640 644 | 2 428 590±429 297 | 2 799 155±348 275 | 0.427 K-W test |
| | Treatment | | | | |
| | 3D combo | 83 (70.3) | 43 (53.8) | 96 (57.8) | <0.0001 | | SOF LDV | 21 (17.8) | 35 (43.8) | 64 (38.6) | | other | 14 (11.9) | 2 (2.5) | 6 (3.6) |
| | Ribavirin | 19 (16.2) | 18 (22.8) | 106 (63.9) | <0.0001 |
| | Treatment duration | | | | |
| | <8 weeks (incomplete) | 4 (3.4) | 1 (1.3) | 4 (2.4) | 0.611 | | 8 weeks | 2 (1.7) | 0 | 0 | | 12 weeks | 109 (93.2) | 76 (95) | 155 (93.4) | | 24 weeks | 2 (1.7) | 3 (3.8) | 7 (4.2) |
| | SVR | 89 (96.7) | 74 (97.4) | 144 (96.0) | 0.862 |
| | Creatinine umol/L (n=366) | 139.5±17.5 | 84.2±6.2 | 79.9±5.8 | <0.0001 |
| | CRP mg/dL (n=127) | 3.5±0.78 | 4.3±1.60 | 1.6±0.19 | 0.012 |
| | Hb g/L (n=368) | 142±1.7 | 144±2 | 138±1.4 | 0.023 |
| | Neutrophils 109/L (n=258) | 4.01±0.18 | 3.32±0.17 | 2.8±013 | <0.0001 |
| | Platelets 109/L (n=368) | 206±6.9 | 200±7.5 | 132±5 | <0.0001 |
| | AFP kIU/L (n=240) | 5.4±0.9 | 7.6±0.6 | 22.3±0.2 | <0.0001 |
| | Albumin g/L (n=354) | 41.6±0.4 | 41.5±0.4 | 38.6±0.4 | <0.0001 |
| | INR (n=335) | 1.02±0.02 | 1.05±0.03 | 1.13±0.01 | <0.0001 |
| | AST %ULN (n=281) | 133.6±14.5 | 145.6±10.0 | 234.3±14.9 | <0.0001 |
| | ALT %ULN (n=368) | 175.40±14.2 | 166.2±10.8 | 229.5±13.9 | 0.002 |
| | GMT %ULN (n=281) | 154.6±15.6 | 144.3±14.4 | 241.5±30.4 | 0.01 |
| | ALP %ULN (n=281) | 76.7±4.1 | 69.1±2.9 | 92.9±4.1 | <0.0001 |
| | Bilirubin umol/L (n=368) | 12.9±1.0 | 13.2±0.5 | 19.7±1.0 | <0.0001 |
| | Conj. Bil. umol/L (n=184) | 5.4±1.6 | 3.6±0.3 | 8.5±1.03 | 0.01 |
| | Glucose (mmol/l) | 5.75±0.18 | 5.84±0.17 | 6.69±0.2 | 0.001 |
| | Total cholesterol (mmol/L) n=328 | 4.45±0.10 | 4.69±0.10 | 4.19±0.08 | 0.001 |
| | HDL-C (mmol/L) n=140 | 1.34±0.05 | 1.32±0.07 | 1.27±0.06 | 0.622 |
| | LDL-C (mmol/L) n=136 | 2.73±0.12 | 2.48±0.15 | 2.33±0.09 | 0.02 |
| | Triglycerides (mmol/L) n=201 | 1.37±0.08 | 1.27±0.10 | 1.54±0.09 | 0.165 |
| | AIP n=140 | -0.03±0.03 | -0.03±0.05 | 0.04±0.04 | 0.272 |
| | FORNS | 5.74±0.23 | 6.18±0.23 | 8.19±0.18 | <0.0001 |
| | FIB-4 | 1.8±0.15 | 2.55±0.27 | 5.77±0.54 | <0.0001 |
| | APRI | 0.76±0.09 | 0.9±0.1 | 2.27±0.18 | <0.0001 |
| | TELP (kPa) | 6.14±0.23 | 7.61±0.47 | 20.07±1.27 | <0.0001 |
|
|
