Microsatellite Instability in Mouse Models of Colorectal Cancer

Figure 4

AOM-treated Msh2-KO mice display further contraction of the mononucleotide repeats in the distal colon. (a, f) Bat37 and Bat59 in the colon of a WT mouse; (b–d); (g–i) AOM-induced tumors from a Msh2-KO mouse; (e, j) uninvolved colon tissue from an AOM-treated Msh2-KO mouse. The position of the highest peak in the WT mouse is highlighted with the grey bar; 121 and 187 bp refer to the size of the PCR fragment in the WT and the number in the top right corner indicates the number of nucleotides by which the repeat is shortened in the Msh2-KO mouse.