Research Article

Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood

Table 2

Biological process networks for 974 genes whose expression was negatively correlated with CD4+ peripheral blood cells and Eotaxin.

NetworksTotalP valueFalse discovery rateIn dataNetwork objects from active data

Proteolysis_ECM remodeling855.38E-057.21E-0310Collagen XIV, Tenascin-C, NEPH2, MMP-16, Protein C inhibitor, Serpin B12, COL18A1, Kallikrein 2, Trypsin II, Aggrecanase-1

Neurophysiological process_Transmission of nerve impulse2123.13E-042.10E-0215L-type Ca(II) channel, alpha 1C subunit, GABA-A receptor gamma-2 subunit, KCC2, mGluR3, Galpha(i)-specific peptide GPCRs, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, GluR6, Galpha(i)-specific amine GPCRs, CHT1, RIN, G-protein alpha-s, Kainate receptor

Reproduction_Gonadotropin regulation1991.64E-035.29E-0213L-type Ca(II) channel, alpha 1C subunit, GABA-A receptor gamma-2 subunit, mGluR3, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, Secretogranin 1, Protein kinase G1, Adenylate cyclase, G-protein alpha-s, Protein kinase G, Kainate receptor

Development_Blood vessel morphogenesis2281.97E-035.29E-0214PDE, Galpha(i)-specific peptide GPCRs, PDE7A, Endomucin, Galpha(q)-specific amine GPCRs, Galpha(i)-specific amine GPCRs, Protein kinase G1, Galpha(q)-specific peptide GPCRs, COL18A1, Tissue kallikreins, Neuropilin-1, G-protein alpha-s, Protein kinase G, Transferrin

Reproduction_Spermatogenesis, motility and copulation2281.97E-035.29E-0214PDGF receptor, MFGE8, IGF-1 receptor, Ropporin, MSK1, S5AR2, BBS2, Tissue kallikreins, BMP2, Kallikrein 2, SOX5, CREM (activators), ZFP37, PDGF-R-alpha

Proteolysis_Connective tissue degradation1193.23E-036.80E-029Trypsin, Tenascin-C, MMP-16, Protein C inhibitor, Serpin B12, Tissue kallikreins, Kallikrein 2, Trypsin II, Aggrecanase-1

Development_Neurogenesis in general1923.55E-036.80E-0212WNT4, RET, CHRM, Neuromodulin, WNT7A, WNT, Galpha(q)-specific amine GPCRs, Galpha(i)-specific amine GPCRs, HDAC7, ACM3, SOX8, SOX14

Development_Cartilage development666.45E-031.08E-016TR-alpha, Noggin, COL1A2, BMP2, SOX5, Aggrecanase-1

Reproduction_Male sex differentiation2438.98E-031.30E-0113AP-2A, PDGF receptor, Olfactory receptor, RET, IGF-1 receptor, MSK1, S5AR2, HSF2, BMP2, SOX5, CREM (activators), ZFP37, PDGF-R-alpha

Reproduction_GnRH signaling pathway1669.70E-031.30E-0110GABA-A receptor gamma-2 subunit, mGluR3, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, Protein kinase G1, G-protein alpha-s, Protein kinase G, Kainate receptor