Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study

Table 3

Epidemiological, anthropometric, and genetic data of the noncirrhotic NAFLD group divided into two subgroups according to the degree of fibrosis: absent/mild (F0-F1) and advanced (F2-3).

	F0-1	F2-3
	51	42
Age (years)	46.7 (13.1)	57.5 (11)	<0.001
Sex (male)	64.7%	54.8%	0.332
BMI (Kg/m^2)	28.5 (3.8)	30.8 (4.2)	0.012
T2DM	31.4%	61.9%	0.006
PNPLA3
G allele frequency	0.44	0.54	0.203
CC	19 (37.3%)	11 (26.2%)	0.491
CG	19 (37.3%)	17 (40.5%)
GG	13 (25.5%)	14 (33.3%)
TM6SF2
T allele frequency	0.09	0.14	0.375
CC	42 (82.4%)	32 (76.2%)	0.278
CT	9 (17.6%)	8 (19%)
TT	0 (0%)	2 (4.8%)
KLF6
T allele frequency	0.06	0.08	0.781
CC	45 (88.2%)	35 (83.3%)	0.705
CT	6 (11.8%)	7 (16.7%)
TT	0 (0%)	0 (0%)
SOD2
T allele frequency	0.56	0.49	0.395
CC	9 (17.6%)	11 (26.2%)	0.58
CT	27 (52.9%)	21 (50%)
TT	15 (29.4%)	10 (23.8%)
LPIN1
T allele frequency	0.31	0.32	1
CC	26 (51%)	19 (45.2%)	0.585
CT	18 (35.3%)	19 (45.2%)
TT	7 (13.7%)	4 (9.5%)
SCORE (linear)	1.2 (0.9)	1.5 (1)	0.139

Data are shown as mean (standard deviation), percentages, or absolute number and column percentages. NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; BMI: body mass index; T2DM: type 2 diabetes mellitus; PNPLA3: patatin-like phospholipase domain containing protein 3; TM6SF2: transmembrane 6 superfamily member 2; KLF6: Kruppel-like factor 6; SOD2: superoxide dismutase 2; LPIN1: lipin 1.