Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study
Table 4
Uni- and multivariable regression models for the association of the genetic score (modelled as numeric or as factor variable) and presence of NASH cirrhosis or noncirrhotic NAFLD.
NASH cirrhosis versus noncirrhotic NAFLD
Noncirrhotic NAFLD versus healthy controls
NASH cirrhosis versus healthy subjects
OR
aOR
OR
aOR
OR
aOR
Score
1.54 (1.14–2.1)
1.51 (1.04–2.22)
2.05 (1.46–2.93)
2.22 (1.40–3.65)
3.01 (2.14–4.38)
3.62 (1.63–9.69)
Score = 0
ref
ref
ref
ref
ref
ref
Score = 1
1.62 (0.69–3.9)
2.07 (0.69–6.45)
3.40 (1.63–7.28)
4.59 (1.74–12.91)
5.50 (2.46–13.00)
15.40 (2.32–149)
Score = 2
2.18 (0.93–5.29)
2.5 (0.84–7.79)
3.33 (1.55–7.36)
4.38 (1.58–13.05)
7.28 (3.24–17.35)
18.54 (2.78–176)
Score = 3
3.83 (1.4–11.14)
3.66 (1.04–13.75)
23.00 (4.01–436.62)
21.98 (2.73–496.88)
88.17 (16.11–1658)
125.37 (4.22–19336)
OR: odds ratio; aOR: adjusted odds ratio. aOR are adjusted for age, sex, BMI, and diabetes mellitus.
