|
| | Metabolic Role | Cytoskeletal or Cell Junction Role |
|
| hsa-miR-10b-5p | Striatal metabolism in Huntington’s Disease [35] | Regulates cytoskeletal RhoC in glioblastoma [36] |
|
| hsa-miR-1254 | Interacts with structured elements in cell cycle and apoptosis regulator 1 (CCAR1) 5’ Untranslated Region [37] | Associated with miR export and processing between nuclear and cytoplasmic compartments [32]; Associated with invasive Retinoblastoma pathogenesis [38] |
|
| hsa-miR-1301-3p | Altered level in Low-Onset Hypogonadism [39]; Downregulates maternal circulating leptin levels [40] | Inhibits migration and invasion of HepG2 hepatic carcinoma cells [41] |
|
| hsa-miR-18b-5p | Interacts with insulin growth factor-1 to downregulate proliferation of human retinal endothelial cells grown in high-glucose media [12]; Increases plaque buildup, leading to atherosclerosis [42] | Modulates genes involved in cell migration and upregulated in breast cancer [43] |
|
| hsa-miR-190a-3p | Under regulation of estrogen receptor (ER) signaling [44] | Inhibits epithelial-mesenchymal transition of hepatoma cells [45]; Targets protease-activated-receptor 1 (PAR-1), which is a metastasis promoting protein [44] |
|
| hsa-miR-223-3p | Inversely correlated with insulin-like growth factor 1 levels [46]; Regulates osteoclast and osteoblast differentiation, leading to regulation of bone metabolism [47]; Downregulates glucose uptake controlled by insulin in the adipose tissue of insulin-resistant women [48]; Upregulates glucose uptake in cardiomyocytes via the glucose transporter 4 protein [49]; Regulates multiple pathways involved in cholesterol uptake and metabolism [50]; Downregulates high-density lipoprotein uptake [51] | Regulates epithelial mesenchymal transition [52] |
|
| hsa-miR-342-5p | Involved in regulatory T cell function in Type I Diabetes Mellitus [53] | Targets DNA methyltransferase 1 and inhibits colorectal cancer cell proliferation and invasion [54] |
|
| hsa-miR-3614-3p | Regulates the OLR1 gene which encodes for the lectin-like oxidized low-density lipoprotein receptor-1 protein [55] | Involved in c-Myc-regulated migration and angiogenesis [56] |
|
| hsa-miR-566 | Activates epidermal growth factor receptor signaling in glioblastoma cells [57] | Associated with metastatic colon cancer patient profile [58] |
|
| hsa-miR-675-5p | Inhibits the expression of insulin-like growth factor 1 receptor and insulin receptor in rhabdomyosarcoma cells [59] | Upregulates collagen proteins in the cartilage matrix of human articular chondrocytes [60]; Regulates tight junction proteins in intestinal epithelial barrier [61] |
|
| hsa-miR-890 | Regulates tumor DNA repair [62] | Regulates autophagy and metastasis-associated Rad23B protein in prostate cancer [62] |
|
