Top canonical pathways, top diseases and biological functions, and top toxicology functions revealed by the eleven common miR targets of the MetS-FL trio, ZO-1, and Occludin.
Top Canonical Pathways
p-value
Tight Junction Signaling
0.00255
Sertoli Cell-Sertoli Cell Junction Signaling
0.00277
Germ Cell-Sertoli Cell Junction Signaling
0.0763
Top Upstream Regulators
p-value
Gelatinase
5E-07
ERP29
4.66E-06
MMP9
0.000013
CAV1
1.75E-05
MMP2
2.54E-05
Top Diseases and Disorders
p-value
Inflammatory Response
0.00000116 - 0.0013
Cancer
0.00000659 - 0.0474
Hematological Disease
0.00000659 - 0.0316
Immunological Disease
0.00000659 - 0.0426
Organismal Injury and Abnormalities
0.00000659 - 0.0472
Top Molecular and Cellular Functions
p-value
Cell Death and Survival
0.000000194 - 0.0121
Cell-To-Cell Signaling and Interaction
0.00000116 - 0.0318
Cellular Function and Maintenance
0.00000116 - 0.0300
Energy Production
0.000190 - 0.000190
Molecular Transport
0.000190 - 0.000190
Top Tox Functions (Hepatotoxicity)
p-value
Liver Necrosis/Cell Death
0.00420 – 0.00420
Hepatocellular Carcinoma
0.345 – 0.345
Liver Hyperplasia/Hyperproliferation
0.345 – 0.596
: endoplasmic reticulum protein 29; MMP: matrix metallo-proteinase; CAV1: caveolin-1.
