Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis

Table 1

Clinical characteristics of 27 studies included in meta-analysis.

Author	Year	Ethnicity	LncRNAs	Sample types	SEN	SPE	Pat(n)	Con (n)	AUC	REF
El-Tawdi AH	2016	African	UCA1	serum	0.914	0.886	70	38	0.91	[28]
El-Tawdi AH	2016	African	CTBP	serum	0.91	0.885	78	44	0.91	[29]
El-Tawdi AH	2016	African	CTBP	serum	0.91	0.75	78	36	0.83	[29]
Jing W	2016	Asian	SPRY4-IT1	plasma	0.783	0.5	60	63	0.702	[26]
Jing W	2016	Asian	GAS5	plasma	0.877	0.485	117	129	0.734	[26]
Jing W	2016	Asian	GAS5	plasma	0.833	0.491	117	55	0.688	[26]
Kamel MM	2016	African	UCA1	serum	0.927	0.821	82	44	0.861	[21]
Kamel MM	2015	African	WRAP53	serum	0.854	0.821	82	44	0.896	[21]
Kamel MM	2015	African	UCA1	serum	0.61	0.71	82	34	0.728	[21]
Kamel MM	2015	African	WRAP53	serum	0.854	0.71	82	34	0.787	[21]
Li J	2015	Asian	HULC	plasma	0.65	0.92	66	53	0.78	[20]
Li J	2015	Asian	Linc00152	plasma	0.768	0.902	66	53	0.85	[20]
Li J	2015	Asian	HULC, Linc00152	plasma	0.798	0.904	66	53	0.87	[20]
Lu JJ	2014	Asian	AF085935	serum	0.963	0.966	137	138	0.96	[22]
Lu JJ	2014	Asian	uc003wbd	serum	0.778	0.843	137	138	0.86	[22]
Lu JJ	2014	Asian	AF085935	serum	0.912	0.794	137	104	0.86	[22]
Lu JJ	2014	Asian	uc003wbd	serum	0.653	0.781	137	104	0.7	[22]
Ma WJ	2016	Asian	JPX	plasma	1	0.524	42	68	0.814	[30]
Peng W	2015	Asian	PANDAR	tissue	0.895	0.891	482	482	0.956	[23]
Tang JW	2015	Asian	RP11-160H22.5, XLOC_014172	plasma	1	0.95	20	20	1	[19]
			LOC149086
Tang JW	2014	Asian	RP11-160H22.5, XLOC_014172	plasma	0.82	0.73	147	180	0.9	[19]
			LOC149086
Tang JW	2014	Asian	RP11-160H22.5	plasma	0.85	0.953	20	20	0.9	[19]
Tang JW	2014	Asian	RP11-160H22.5	plasma	0.496	0.808	147	180	0.601	[19]
Tang JW	2014	Asian	XLOC_014172	plasma	0.95	0.95	20	20	0.95	[19]
Tang JW	2014	Asian	XLOC_014172	plasma	0.81	0.923	147	180	0.866	[19]
Tang JW	2014	Asian	LOC149086	plasma	0.8	0.953	20	20	0.875	[19]
Tang JW	2014	Asian	LOC149086	plasma	0.762	0.757	147	180	0.759	[19]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.95	0.881	121	232	0.949	[27]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.975	0.831	81	232	0.937	[27]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.957	0.881	70	232	0.945	[27]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.787	0.909	61	120	0.949	[27]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.846	0.884	37	120	0.953	[27]
Wang K	2015	Asian	uc001ncr, AX800134	serum	0.811	0.909	37	120	0.956	[27]
Wang K	2015	Asian	uc001ncr	serum	0.875	0.799	121	232	0.886	[27]
Wang K	2015	Asian	uc001ncr	serum	0.927	0.877	121	232	0.925	[27]
Wang K	2015	Asian	AX800134	serum	0.918	0.926	61	120	0.947	[27]
Wang K	2015	Asian	AX800134	serum	0.934	0.821	61	120	0.888	[27]
Wang X	2016	Asian	LINC01225	serum	0.761	0.88	66	70	0.886	[31]
Xie H	2013	Asian	HULC	plasma	0.9	0.9	30	20	0.86	[25]
Yu JY	2016	Asian	PVT1, uc002mbe.2	serum	0.601	0.901	40	33	0.764	[24]
Yuan WD	2017	Asian	Linc00152	plasma	0.92	0.709	100	100	0.869	[32]
Yuan WD	2017	Asian	RP11-160H22.5	plasma	1	0.811	100	100	0.884	[32]
Yuan WD	2017	Asian	XLOC_014172	plasma	0.978	0.668	100	100	0.759	[32]
Yuan WD	2017	Asian	Linc00152	plasma	0.846	0.695	100	100	0.826	[32]
Yuan WD	2017	Asian	RP11-160H22.5	plasma	1	0.778	100	100	0.859	[32]
Yuan WD	2017	Asian	XLOC_014172	plasma	0.981	0.673	100	100	0.735	[32]
Yuan WD	2017	Asian	Linc00152, RP11-160H22.5	plasma	0.978	0.957	100	100	0.986	[32]
			XLOC_014172
Yuan WD	2017	Asian	Linc00152, RP11-160H22.5	plasma	0.981	0.961	100	100	0.985	[32]
			XLOC_014172
Zheng ZK	2017	Asian	UCA1	serum	0.733	0.99	105	105	0.902	[33]
Zhou JW	2015	Asian	KLF4-003	tissue	0.889	0.611	54	54	0.803	[34]

SEN: sensitivity; SPE: specificity; Pat: patient; Con: control; AUC: area under the curve; REF: reference.