Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity

Figure 2

AFP-a sword with two blades. As an oncofetal antigen and diagnostic marker for liver cancer, AFP is a sword with two blades. AFP promoted tumor proliferation, invasion, angiogenesis, and escaping from immune surveillance, which could be an ideal target for immunotherapy. On the other side, AFP-modified DNA, protein, peptide vaccine, or DC cell vaccine displayed the specific antitumor immunity against AFP-positive liver cancers.