Characteristics and Changes over Time of Alcohol-Related Chronic Liver Diseases in Italy

Table 5

Characteristics of 955 subjects with alcohol-related liver cirrhosis in Italy, by year of recruitment.

Characteristics	Overall	Study 2001	Study 2014	p-value
	(n°=955)	(n°=792)	(n°=163)
Age (years), mean ± SD				0.4
Sex Ratio (M/F)	2.9	3.6	1.3	<0.001
BMI, mean ± SD				0.3
Area of origin
(i) Northern/Central Italy	423 (44.2%)	349 (44.1%)	74 (45.4%)	0.005
(ii) Southern Italy/Islands	510 (53.3%)	429 (54.2%)	79 (48.5%)
(iii) Born abroad	24 (2.5%)	14 (1.8%)	10 (6.1%)
Risk factors
(i) Alcohol intake alone	459 (48.0%)	374 (47.2%)	85 (52.1%)	0.7
(ii) Alcohol intake/HBsAg positive	63 (6.6%)	54 (6.8%)	9 (5.5%)
(iii) Alcohol intake/anti-HCV positivity	407 (42.5%)	340 (42.9%)	65 (39.9%)
(iv) Alcohol intake/HBsAg positive/anti-HCV positive	28 (2.9%)	24 (3.0%)	4 (2.5%)
Diagnosis
(i) Liver cirrhosis without HCC	836 (87.4%)	697 (88.0%)	137 (84.0%)	0.2
(ii) Liver cirrhosis with HCC	121 (12.6%)	95 (12.0%)	26 (16.0%)
Child-Pugh class
(i) A	381 (45.6%)	307 (44.1%)	74 (54.0%)	0.04
(ii) B/C	455 (54.4%)	390 (55.9%)	63 (46.0%)

BMI: body mass index. HCC: hepatocellular carcinoma.