Canadian Journal of Gastroenterology and Hepatology / 2018 / Article / Tab 1

Research Article

Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease

Table 1

Demographic characteristics of examined cohort.

Examined (40)Control (36)Difference and significance

Age (yrs., mean ± SD)47.88 ± 6.0747.07 ± 6.68NS
Sex (male/female)22/1816/14NS
Body mass index (BMI, kg/m2, mean ± SD)32.04 ± 6.6722.18 ± 4.43
Diabetes type 2 (yes/no)12/289/27NS
Hypertension (yes/no)32/816/20
Spearman correlation NAFLD + and hypertension,
HDL/LDL ratio (mean ± SE)4.49 ± 0.232.94 ± 0.18
Status according to BMI:
Normal521
Overweight1511
Obese204
Metabolic syndrome (yes/no)34/68/28Chi square,
MoCA score (mean ± SD)24.07 ± 3.1827.17 ± 2.35
Total brain volume (cm3, mean ± SD)1388 ± 127.981417 ± 191.83NS
Gray matter volume (gmw in cm3 mean ± SD)405 ± 37.42414 ± 56.09NS
White matter volume (wmw, in cm3 mean ± SD)338 ± 31.21344 ± 46.83NS
Lateral ventricle volume, right/left (lvlr, lvll, in cm3 mean ± SD)5.97 ± 0.616.07 ± 0.625.64 ± 0.375.63 ± 0.37
AST (U/l, mean ± SE)39.97 ± 2.6124.03 ±3.26
ALT (U/l mean ± SE)39.11 ± 2.8636.71 ± 3.5NS
AST/ALT ratio (mean ± SE)1.13 ± 0.110.7 ± 0.06
C-reactive protein (mg/l, mean ± SE)3.96 ± 0.453.52 ± 0.51NS
Fasting glycaemia (mmol/l, l mean ± SE)5.8 ± 0.193.71 ± 0.25
Triglycerides (mmol/l, l mean ± SE)2.87 ± 0.181.71 ± 0.17

NS, not significant; SE, standard error. Lateral ventricle volumes.