Review Article
Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma
Table 4
Main characteristics of 11 articles included in prognostic meta-analysis.
| | Author, year | Country | Case | circRNAs | Altered expression | Specimen type | Method | Reference gene | Outcome | Follow-up (month) | Expression related to poor prognosis | HR (95%CI) | Analysis method | NOS (scores) |
| | Chen et al. 2018 | China | 78 | hsa_circ_0128298 | Up | tissue | qRT-PCR (SYBR) | GAPDH | OS | ~67 | Up | 6.661 (2.661-8.418) | Multivariate | 6 | | Huang et al. 2017 | China | 80 | circRNA_100338 | Up | tissue | qRT-PCR (SYBR) | GAPDH | OS | ~120 | Up | 2.75 (1.01-7.52) | Kaplan-Meier curves | 7 | | Yu et al. 2018 | China | 163 | cSMARCA5 | down | tissue | qRT-PCR (SYBR) | GAPDH | OS
RFS | ~60 | down | 2.47 (1.459-4.182)
1.673 (1.08-2.591) | Multivariate | 7 | | Xu et al. 2017 | China | 95 | ciRS-7 | Up | tissue | qRT-PCR (SYBR) | GAPDH | RFS | ~63 | Up | 1.17 (0.58 - 2.38) | Multivariate | 7 | | Zhong et al. 2018 | China | 47 | CircC3P1 | down | tissue | qRT-PCR (SYBR) | b-actin | OS | ~60 | down | 0.62 (0.11 - 3.39) | Kaplan-Meier curves | 6 | | Zhang et al. 2018 | China | 77 | hsa_circ_0001649 | down | tissue | qRT-PCR (SYBR) | GAPDH | OS | ~45 | down | 0.191 (0.053-0.682) | Multivariate | 7 | | Guo et al. 2017 | China | 288 | circ-ITCH | down | tissue | qRT-PCR (SYBR) | GAPDH | OS | ~83 | down | 0.45 (0.29 - 0.68) | Multivariate | 6 | | Han et al. 2017 | China | 116 | circMTO1 | down | tissue | FISH | - | OS | ~80 | down | 0.34 (0.22 - 0.51) | Kaplan-Meier curves | 5 | | Li et al. 2018 | China | 51 | circRNA101368 | Up | tissue | qRT-PCR (SYBR) | GAPDH | OS | ~60 | Up | 3.246 (1.098-9.594) | Multivariate | 6 | | Liu et al. 2018 | China | 70 | circ_001569 | Up | tissue | qRT-PCR (SYBR) | NA | OS | ~60 | Up | 2.291 (1.059-4.954) | Multivariate | 7 | | Weng et al. 2018 | China | 120 | hsa_circ_0064428 | down | tissue | qRT-PCR (SYBR) | NA | OS | ~72 | down | 0.36 (0.22-0.58) | Kaplan-Meier curves | 7 |
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qRT-PCR: quantitative reverse transcription PCR; FISH: fluorescence in situ hybridization; OS: overall survival; RFS: recurrence free survival; NA: not available; HR: hazard ratio; NOS: the Newcastle-Ottawa scale.
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