Research Article
Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Table 1
Characteristics of the included studies.
| First author | Year | Country | MicroRNAs | Regulation mode | Disease | Sample size | Male N (%) | Diagnostic power | Case | Control | Sen (%) | Spe (%) |
| Y. Tan | 2014 | China | miR-122-5p | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 93.4 | 46.7 | Y. Tan | 2014 | China | miR-1290 | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 58.6 | 65.6 | Y. Tan | 2014 | China | miR-27b-3p | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 59.9 | 72.7 | Y. Tan | 2014 | China | miR-192-5p | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 34.9 | 93.3 | Y. Tan | 2014 | China | miR-148a-3p | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 69.1 | 41.1 | Y. Tan | 2014 | China | miR-99a-5p | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 25.7 | 90 | Y. Tan | 2014 | China | 6miRs panel | Upregulated | NAFLD | 152 | 90 | 195 (80.5) | 90.3 | 76.2 | N. C. Salvoza | 2016 | America | miR-34a | Upregulated | NAFLD | 28 | 36 | 35 (54.7) | 75 | 75 | N. C. Salvoza | 2016 | America | miR-122 | Upregulated | NAFLD | 28 | 36 | 35 (54.7) | 78.6 | 77.8 | M. Celikbilek | 2014 | Turkey | miR-197 | Downregulated | NASH | 20 | 20 | 18 (45.0) | 60 | 95 | M. Celikbilek | 2014 | Turkey | miR-146b | Downregulated | NASH | 20 | 20 | 18 (45.0) | 55 | 100 | M. Celikbilek | 2014 | Turkey | miR-181d | Downregulated | NASH | 20 | 20 | 18 (45.0) | 70 | 85 | M. Celikbilek | 2014 | Turkey | miR-99a | Downregulated | NASH | 20 | 20 | 18 (45.0) | 65 | 95 | X. L. Liu | 2016 | China | miR-34a | Upregulated | NASH | 31 | 37 | 40 (58.8) | 70.4 | 87.5 | T. Auguet | 2016 | Spain | miR122 | Upregulated | NAFLD | 61 | 39 | 0 (0.0) | 96.6 | 54, 7 | K. Jampoka | 2018 | Thailand | miR-29a | Downregulated | NAFLD | 58 | 34 | ā | 60.37 | 82.35 | K. Jampoka | 2018 | Thailand | miR-122 | Upregulated | NAFLD | 58 | 34 | ā | 75 | 82.35 |
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Sen: sensitivity; Spe: specificity.
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