Research Article
Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Table 2
Summary estimates of diagnostic power and their 95% confidence intervals.
| Subgroup | Sensitivity (95% CI) | Specificity (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) | DOR (95% CI) | AUC |
| Regulation mode | Upregulated | 12 | 0.73 [0.58–0.84] | 0.77 [0.63–0.87] | 3.15 [2.04–4.85] | 0.35 [0.23–0.54] | 8.99 [4.88–16.75] | 0.82 [0.78–0.85] | Downregulated | 5 | 0.61 [0.53–0.69] | 0.91 [0.81–0.96] | 7, 18 [3.06–16.71] | 0.42 [0.34–0.53] | 17.04 [6.49–44.75] | 0.65 [0.61–0.69] |
| Country | Chinese | 8 | 0.66 [0.47–0.82] | 0.79 [0.58–0.91] | 3.21 [1.62–6.36] | 0.42 [0.27–0.67] | 7.58 [3.24–17.78] | 0.79 [0.75–0.82] | Non-Chinese | 9 | 0.73 [0.61–0.82] | 0.83 [0.74–0.90] | 4.36 [2.98–6.36] | 0.32 [0.23–0.46] | 13.46 [8.48–21.26] | 0.86 [0.82–0.89] |
| miRNA profiling | miRNA panel | 1 | 0.90 | 0.76 | 3.86 | 0.42 | 9.13 | 0.89 | Single miRNA | 16 | 0.68 [0.56–0.78] | 0.83 [0.71–0.90] | 3.90 [2.42–6.28] | 0.39 [0.29–0.52] | 9.96 [5.67–17.52] | 0.82 [0.78–0.85] |
| Sample size | ≥100 | 9 | 0.72 [0.53–0.85] | 0.77 [0.59–0.88] | 3.05 [1.84–5.06] | 0.37 [0.23–0.60] | 8.19 [4.06–16.54] | 0.81 [0.77–0.84] | <100 | 8 | 0.69 [0.60–0.76] | 0.89 [0.79–0.94] | 5.96 [3.20–11.12] | 0.36 [0.28–0.46] | 16.67 [8.27–33.98] | 0.81 [0.78–0.84] |
| Male proportion | >50% | 10 | 0.69 [0.52–0.81] | 0.78 [0.62–0.89] | 3.16 [1.87–5.35] | 0.40 [0.27–0.60] | 7.88 [3.97–15.63] | 0.80 [0.76–0.83] | ≤50% | 5 | 0.77 [0.69–0.84] | 0.81 [0.72–0.87] | 5.92 [1.96–17.85] | 0.35 [0.22–0.54] | 25.90 [10.99–61.06] | 0.90 [0.88–0.92] |
| Disease | NAFLD | 12 | 0.72 [0.57–0.84] | 0.76 [0.62–0.86] | 3.05 [2.01–4.62] | 0.36 [0.24–0.55] | 8.40 [4.63–15.24] | 0.81 [0.77–0.84] | NASH | 5 | 0.65 [0.55–0.73] | 0.92 [0.83–0.97] | 8.27 [3.74–18.31] | 0.38 [0.29–0.50] | 21.62 [8.71–53.66] | 0.80 [0.76–0.83] | Total | 17 | 0.70 [0.58–0.79] | 0.82 [0.72–0.90] | 3.95 [2.54–6.15] | 0.37 [0.27–0.50] | 10.76 [6.26–18.51] | 0.83 [0.79–0.86] |
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LR: likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve; CI: confidence interval.
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