HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation

Figure 1

DAA therapy pre- and post-liver transplantation. There was a significant increase in pre-transplant utilization of DAA therapy between 2014 (N=5 patients treated pre-LT) and 2015 (N=12 LT patients treated pre-LT) (panel (a)). Among those treated with DAA pre-LT in 2014, the rate of SVR was 80%, with only 18.1% (N=4/22) of all patients with SVR pre-LT. In 2015, 100% of N=12 patients treated pre-LT achieved SVR, representing 54.5% of all patients transplanted in 2015. A high proportion of patients who were untreated at the time of transplant (N=17 patients in 2014 and N=11 patients in 2015) were treated with DAA post-LT, with 100% of those patients achieving SVR post-LT in 2014 and 60% achieving SVR post-LT in 2015 (panel (b)). The mean time to SVR significantly improved between 2014 and 2015 (c). A high proportion of untreated post-LT patients (N=23/28) underwent biopsy, and N=12/23 patients had at least F1 METAVIR fibrosis prior to starting DAA. Data are presented as mean ± SD.

(a) DAA usage pre-transplant

(b) DAA usage post-transplant

(c) Mean time to HCV SVR post-transplant

(d) Rates of METAVIR fibrosis in patients treated with DAA post-transplant