Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases

Figure 1

(a) Transcription profile of LLGL1 in 5 gastric cancer cell lines and in 12 representative gastric cancer samples. LLGL1 and E-cadherin reveal a similar transcription pattern in gastric cancer. (b) LLGL1 immunostaining in gastric mucosa. Negative controls remained negative. LLGL1 expression is absent in the basal part of the gland and strong at the foveolar top. LLGL1 reveals a membranous localization within the mucosa cells. (c) LLGL1 staining of gastric cancer samples. The figure depicts the expression patterns of LLGL1 in gastric cancer (absent versus positive). Loss of LLGL1 significantly correlated with diffuse gastric cancer.

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