Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy

Table 3

Individual efficacy data depending on HCV genotype, hepatic fibrosis, and primary and rescue regimen.

Patient	Fibrosis	GT	Primary regimen	Response to primary reg.	Months between therapies	Rescue regimen	Response to rescue reg.
1	4	3	OBV/PTV/r+DSV+RBV	REL	6	LDV/SOF+RBV, 12wks	NR
2	4	1B	OBV/PTV/r+DSV+RBV	DSC, 1wk	1	LDV/SOF+RBV, 12wks	SVR
3	4	1B	OBV/PTV/r+DSV+RBV	DSC, 2wks	11	LDV/SOF, 12wks	LFU
4	4	1B	OBV/PTV/r+DSV+RBV	DSC, 3wks	11	LDV/SOF, 24wks	SVR
5	1	1B	OBV/PTV/r+DSV	DSC, 4 wks	5	LDV/SOF, 12wks	SVR
6	4	1B	OBV/PTV/r+DSV+RBV	DSC, 4 wks	2	LDV/SOF, 24wks	SVR
7	1	1B	OBV/PTV/r+DSV	DSC, 1 wk	2	LDV/SOF, 12wks	SVR
8	4	1B	OBV/PTV/r+DSV+RBV	DSC, 2wks	17	LDV/SOF, 12wks	SVR
9	4	1B	OBV/PTV/r+DSV+RBV	DSC, 3wks	10	LDV/SOF+RBV, 12wks	SVR
10	4	1B	OBV/PTV/r+DSV+RBV	DSC, 4wks	9	LDV/SOF, 24wks	SVR
11	3	1B	OBV/PTV/r+DSV	NR	12	LDV/SOF+RBV, 12wks	SVR
12	1	1B	OBV/PTV/r+DSV	DSC, 1 day	7	LDV/SOF, 8wks	SVR
13	4	3	SOF+RBV	REL	3.5	SOF+DCV, 12wks →; SOF+RBV, 12wks	SVR
14	2	4	SOF+RBV	NR	6	GZR/EBR, 12wks	SVR
15	4	3	SOF+RBV	REL	8	SOF+DCV+RBV 24wks	SVR
16	4	1B	LDV/SOF+RBV	REL	9	LDV/SOF+RBV, 24wks	NR
17	4	4	LDV/SOF+RBV	REL	8	GZR/EBR, 12wks	LFU
18	3	4	LDV/SOF	NR	16	OBV/PTV/r+RBV, 24wks	SVR
19	2	1B	LDV/SOF	REL	16	OBV/PTV/r+DSV, 12wks	SVR
20	0	4	LDV/SOF	REL	7	GZR/EBR+RBV, 16wks	SVR
21	4	1B	LDV/SOF+RBV	NR	17	LDV/SOF+RBV, 24wks	SVR
22	4	1B	LDV/SOF+RBV	NR	14	SOF+DCV+RBV 24wks	NR
23	4	1B	ASV+DCV	NR	4	OBV/PTV/r+DSV+RBV, 12wks	NR
24	4	4	ASV+DCV	UKN	0	OBV/PTV/r+RBV, 24wks	SVR
25	4	1B	ASV+DCV	NR	12	LDV/SOF+RBV, 24wks	SVR
26	4	1B	SMV+SOF+RBV	REL	13	LDV/SOF+RBV, 24wks	SVR
27	4	1B	SOF+DCV+RBV	NR	4	GZR/EBR, 12wks	SVR
28	4	1B	OBV/PTV/r+DSV+RBV	DSC, 4wks	12	LDV/SOF, 24wks	SVR
29	4	1B	OBV/PTV/r+DSV+RBV	REL	12	LDV/SOF, 24wks	SVR
30	4	1B	OBV/PTV/r+DSV+RBV	REL	7	LDV/SOF, 24wks	SVR
31	2	1B	ASV+DCV	NR	18	OBV/PTV/r+DSV+RBV, 12wks	SVR

GT: genotype; OBV: ombitasvir; PTV: paritaprevir; DSV: dasabuvir; RBV: ribavirin; LDV: ledipasvir; SOF: sofosbuvir; ASV: asunaprevir; DCV: daclatasvir; GZR: grazoprevir; EBR: elbasvir; REL: relapse; DSC: discontinued; NR: nonresponder, UKN: unknown; LFU: lost to follow-up.