Applicability of Oral Fluid and Dried Blood Spot for Hepatitis B Virus Diagnosis

Table 2

Main characteristics of studies that detect HBV-DNA in saliva or oral fluid samples.

Reference	Type of saliva or collection device	Population	Serum HBsAg or HBV	Molecular method	Sensitivity of HBV DNA
					Detection in oral fluid
			DNA positive subjects (n)
[7]	Whole saliva	Thailand HBV carriers	23	In-house qualitative PCR	47.8%
[18]	Whole saliva	Siberian military men	42	In-house qualitative PCR	46.2%
[19]	Whole saliva	HBV chronic carriers	147	In-house real-time PCR	47%
[20]	Whole saliva	HBV chronic carriers	23	In-house real-time PCR	21.7%
[21]	Whole saliva	HBV chronic carriers	200	In-house real-time PCR	72.5%
[22]	Oracol	Children with chronic HBV	46	In-house real-time PCR	92%
[23]	Whole saliva	HBV chronic carriers	50	Commercial PCR	68%
[24]	Salivette, FTA Cards, DNA-Sal and whole saliva	HBV chronic carriers	32	In-house qualitative PCR	53.12%
[25]	Salivette	HBV chronic carriers	55	In-house real-time PCR	18.2%
[26]	Salivette	Occult HBV carriers	5	In-house qualitative PCR	80%