Renal Dysfunction is a Risk Factor of Death after Gastric Endoscopic Submucosal Dissection in Elderly Patients Aged ≥80 Years

Table 5

Univariate and multivariate analyses of the risk factors of death.

	Univariate analysis		Multivariate analysis
	value	HR (95% CI)	value	HR (95% CI)
All patients
Age	0.004	1.06 (1.02–1.10)	0.006	1.07 (1.02–1.12)
Sex (male)	0.074	2.09 (0.93–4.70)	0.10	2.25 (0.86–5.91)
BMI (<22 kg/m^2)	0.085	1.83 (0.92–3.61)	0.076	1.91 (0.93–3.89)
Preoperative eGFR (<30 ml/min/1.73 m^2)	<0.001	6.76 (2.82–16.20)	<0.001	8.09 (2.87–22.80)
Cardiovascular disease	0.016	0.80 (1.16–4.40)	0.18	2.10 (0.72–6.14)
History of cerebrovascular events	0.58	1.39 (0.43–4.50)	—	—
HT	0.48	0.79 (0.42–1.50)	—	—
Anticoagulants and/or antiplatelet drugs	0.029	2.03 (1.08–3.86)	0.586	0.74 (0.26–2.16)
Elderly group
Age	0.73	1.02 (0.88–1.20)	—	—
Sex (male)	0.091	5.80 (0.76–44.59)	0.27	2.41 (0.50–11.54)
BMI (<22 kg/m^2)	0.167	0.33 (0.07–1.59)	—	—
Preoperative eGFR (<30 ml/min/1.73 m^2)	0.018	4.85 (1.32–17.85)	0.015	5.32 (1.39–20.5)
Cardiovascular disease	0.087	2.54 (0.88–7.37)	0.71	1.33 (0.31–5.72)
History of cerebrovascular events	0.25	2.48 (0.53–11.51)	—	—
HT	0.10	0.34 (0.09–1.24)
Anticoagulants and/or antiplatelet drugs	0.05	2.94 (1.03–8.46)	0.34	2.03 (0.47–8.72)
Nonelderly group
Age	0.13	1.04 (0.99–1.10)	—	—
Sex (male)	0.19	1.91 (0.73–5.00)	—	—
BMI (<22 kg/m^2)	0.009	3.03 (1.33–6.93)	0.022	2.68 (1.15–6.24)
Preoperative eGFR (<30 ml/min/1.73 m^2)	0.003	6.19 (1.84–20.88)	0.010	5.14 (1.49–17.70)
Cardiovascular disease	0.24	1.71 (0.70–4.20)	—	—
History of cerebrovascular events	0.76	0.74 (0.10–5.41)	—	—
HT	0.86	1.07 (0.50–2.27)
Anticoagulants and/or antiplatelet drugs	0.38	1.47 (0.63–3.44)

BMI, body mass index; eGFR, estimated glomerular filtration rate; CI, confidence interval; HT, hypertension.