Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma

Table 5

Cox proportional hazard model analysis of p53, p53 Ser 392-P, p53 Ser 15-P, PCNA, age, sex, and clinicopathological factors.

	Exp(B	Significance	Cl (95.0%
p53	0.904	0.398	0.716-1.142
p53 Ser 392-P	0.925	0.696	0.627-1.365
p53 Ser 15-P	0.614	0.013	0.418-0.902
PCNA	1.608	0.002	1.192-2.169
Age	1.093	≤0.001	1.045-1.143
Sex	1.085	0.853	0.456-2.584
Vascular invasion	3.977	0.006	1.484-10.658
Major portal vein invasion	6.289	≤0.001	2.744-14.412
Intrahepatic invasion	3.823	≤0.001	1.970-7.420

Hazard ratio and significance in Cox proportional hazard model analysis. Hazard ratio, Exp(B); Exp(B) < 1 (hazard goes down when factor goes up), Exp(B) >1 (hazard goes up when factor goes up); 95% CIs lower & upper values; significance; P value; , P < 0.05 (significant correlation); , P < 0.01 (highly significant correlation). Cox proportional hazard model test.