Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival

Table 3

Univariate and multivariate Cox regression analysis of survival among patient characteristics.

Variable	Univariate analysis		Multivariate analysis
	HR 95% CI	value	HR 95% CI	value
Gender male vs. female	0.76 (0.47–1.25)	0.285
Age (year) ≤58 vs. >58	0.82 (0.57–1.19)	0.298
KPS		0.321
80 vs. 90	0.93 (0.52–1.66)	0.802
80 vs. 100	1.67 (0.67–4.21)	0.273
Child-Pugh score		0.001
5 vs. 6	1.84 (1.19–2.83)	0.006
5 vs. ≥7	2.52 (1.49–4.26)	0.001
BCLC stage		<0.001		<0.001
A vs. B	1.51 (0.92–2.48)	0.106	1.26 (0.68–2.31)	0.460
A vs. C	3.30 (2.00–5.44)	<0.001	3.68 (1.87–7.22)	<0.001
HBV negative vs. positive	0.99 (0.64–1.51)	0.950
AFP (IU/ml) ≤28.1 vs. >28.1	1.79 (1.17–2.73)	0.007
Tumor thrombus (no vs. yes)	2.69 (1.76–4.11)	<0.001
LNM (no vs. yes)	1.82 (1.10–3.01)	0.020
TACE (no vs. yes)	1.13 (0.78–1.65)	0.514
RFA (no vs. yes)	0.55 (0.26–1.18)	0.125
Tumor size (cm) ≤5.0 vs. >5.0	2.44 (1.68–3.53)	<0.001
BED (Gy) ≤75 vs. >75	0.47 (0.32–0.69)	<0.001
Fractions ≤16 vs. >16	2.79 (1.89–4.12)	<0.001		NI
ALC pre-RT (×10^9/L) ≤1.3 vs. >1.3	0.81 (0.54–1.22)	0.313
ALC post-RT (×10^9/L) ≤0.5 vs. >0.5	0.41 (0.26–0.65)	<0.001
Lymphocyte nadir (×10^9/L) ≤0.5 vs. >0.5	0.31 (0.19–0.49)	<0.001	0.35 (0.19–0.63)	<0.001
GTV (cc) ≤55.0 vs. >55.0	3.00 (2.00–4.51)	<0.001		NI

NI = not included.