Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival

Table 4

Patient characteristics of conventional fractionationated RT (CFRT), hypofractionated RT (HFRT), and stereotactic body RT (SBRT) group.

Characteristic	CFRT (n = 68)	HFRT (n = 58)	SBRT (n = 58)	value
Gender				0.976
Male	56 (82.4)	47 (81.0)	47 (81.0)
Female	12 (17.6)	11 (19.0)	11 (19.0)
Age (y), median (range)	57 (32–78)	58 (32–87)	60 (22–86)	0.301
BCLC stage				<0.001
A	9 (13.2)	14 (24.1)	34 (58.6)
B	31 (45.6)	22 (37.9)	18 (31.0)
C	27 (39.7)	20 (34.5)	3 (5.2)
MV	1 (1.5)	2 (3.4)	3 (5.2)
HBV				0.493
Negative	15 (22.1)	18 (31.0)	14 (24.1)
Positive	53 (77.9)	40 (69.9)	44 (75.9)
Tumor size (cm)				<0.001
≤5	23 (33.8)	23 (39.7)	47 (81.0)
>5	45 (66.2)	34 (58.6)	8 (13.8)
MV	0	1 (1.7)	3 (5.2)
Pre-ALC (×10^9/L), median (range)	1.3 (0.2–3.5)	1.3 (0.4–2.8)	1.4 (0.3–3.5)	0.886
Post-ALC (×10^9/L), median (range)	0.4 (0.1–1.4)	0.4 (0.1–1.4)	0.6 (0.2–2.2)	<0.001
Lymphocyte nadir (×10^9/L), median (range)	0.4 (0.1–1.6)	0.5 (0.1–1.2)	0.7 (0.1–2.6)	<0.001
BED (Gy), median (range)	64.8 (50.0–84.0)	75.0 (58.5–91.1)	86.4 (79.0–119.0)	<0.001
Fraction number	25 (16–35)	15 (10–25)	6 (5–10)	<0.001
GTV (cc), median (range)	190.5 (8.0–1711.3)	94.0 (2.2–1880.1)	15.2 (1.6–126.6)	<0.001

MV = missing value.