Direct Oral Anticoagulant Use and Risk of Diverticular Hemorrhage: A Systematic Review of the Literature

Table 1

Summary of reference articles regarding risk of diverticular bleed in DOAC use.

Author and Year	Method	Population Description	Total Population	Population with diverticular bleed	Population with bleed on DOAC (percentage)
Vajravelu et al 2018 [6]	Retrospective cohort study, 2000-2016	Patients with diverticular hemorrhage	14,925	14,925	237 (1.4%)
Nagata et al 2014 [7]	Prospective study 2009-2013	Patients undergoing colonoscopy	911	153
Taki et al 2017 [8]	Retrospective case identification 2009-2016	Patients with colonic diverticular bleeding and case-matched controls	300	100	7 (2.3%)
Kumar et al 2015 [9]	Retrospective review all patients in a district hospital	Patients taking DOACS in a district hospital	2,487		8
Lai et al 2017 [10]	Retrospective review 2010-2015	Patients taking DOACs	21,503		52
Brodie et al 2018 [11]	Retrospective review 2010-2016	Patients with GI bleed	8,496	31	2 (3.3%)

only 2 patients in total were taking DOACs
54 total GI bleeds, 14% of which were related to diverticular disease
366 total GI bleeds