Effectiveness of Conservative Treatment without Early Colonoscopy in Patients with Colonic Diverticular Hemorrhage
Table 4
Factors associated with recurrent bleeding after spontaneous hemostasis.
Recurrent bleeding
Nonbleeding
Univariate analysis
Multivariate analysis
(n = 29)
(n = 99)
-value
HR (95%CI)
-value
Age (years, mean ± SD)
73.8 ± 11.8
70.5 ± 13.4
0.114
Sex (male)
20 (69.0%)
59 (59.6%)
0.414
Previous history of diverticular hemorrhage
15 (51.7%)
12 (12.1%)
<0.0001
5.63 (2.68–12.0)
<0.0001
Patient on dialysis
3 (10.3%)
7 (7.1%)
0.234
Patient with cirrhosis
1 (3.4%)
1 (1.0%)
0.315
Medications
Aspirin
12 (41.4%)
21 (21.2%)
0.022
1.80 (0.84–3.88)
0.133
Thienopyridine derivative
7 (24.1%)
8 (8.1%)
0.002
3.05 (1.23–7.53)
0.016
Anticoagulants
7 (24.1%)
14 (14.1%)
0.216
NSAIDs
3 (10.3%)
10 (10.1%)
0.607
Systolic blood pressure <90 (mmHg)
2 (6.9%)
9 (9.1%)
0.696
Heart rate (bpm, mean ± SD)
84.4 ± 19.8
88.6 ± 20.9
0.865
Loss of consciousness
4 (13.8%)
13 (13.1%)
0.699
Extravasation on CECT
2 (11.8%)
10 (14.1%)
0.741
Localization of diverticulum (right-sided/left-sided/bilateral)
7/2/20
27/12/60
0.119
Laboratory data
Hemoglobin level (g/dL, mean ± SD)
9.7 ± 2.5
10.8 ± 2.4
0.059
WBC count (×103/mm3, mean ± SD)
7.1 ± 2.5
8.5 ± 2.9
0.177
Platelet count (×104/mm3, mean ± SD)
20.3 ± 6.4
20.7 ± 6.3
0.970
UN/Cre ratio (mean ± SD)
23.1 ± 9.4
23.1 ± 10.9
0.948
Albumin level (g/dL, mean ± SD)
3.5 ± 0.6
3.5 ± 0.5
0.793
PT-INR (mean ± SD)
1.2 ± 0.6
1.2 ± 0.8
0.326
Follow-up period: 31.3 ± 18.6 months. HR, hazard ratio; CI, confidence interval; SD, standard deviation; NSAIDs, nonsteroidal anti-inflammatory drugs; CECT, contrast-enhanced computed tomography; WBC, white blood cells; UN/Cre, urea nitrogen/creatinine; PT-INR, international normalized ratio of prothrombin time. CECT was performed in seventeen patients in the recurrent bleeding group and in seventy-one patients in the nonbleeding group.
