Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells
Table 3
TDI criteria.
Grade of colitis
Microscopic findings
0
No damage
I
Mild mucosal and/or submucosal inflammatory infiltrate and edema: punctuate mucosal erosions often associated with capillary proliferation, muscularis mucosa intact
II
Grade I changes involving 50% of the specimen
III
Prominent inflammatory infiltrate and edema frequently with deeper areas of ulceration extending through the muscularis mucosa into the submucosa, rare inflammatory cells invading the muscularis propria but without muscle necrosis
IV
Grade III changes involving 50% of the specimen
V
Extensive ulceration with coagulative necrosis bordered inferiorly by numerous neutrophils and fewer mononuclear cells; necrosis extends deeply into the muscularis propria
