Research Article

Effects of Anticoagulants on Experimental Models of Established Chronic Liver Diseases: A Systematic Review and Meta-Analysis

Table 5

Analyses for the effect of different anticoagulant therapies on the indices of hepatic damage.

Anticoagulant therapiesEffect estimates of indices of hepatic damage
ALTASTAlbuminTotal bilirubin

Antiplatelet agentsMD −242.29, 95% CI (−409.06, −75.51)MD −1195.30, 95% CI (−1356.24, −1034.36)MD 1.10, 95% CI (0.86, 1.34)MD −1.79, 95% CI (−2.00, −1.59)

LMWHsMD −10.41, 95% CI (−24.45, 3.63)MD −25.17, 95% CI (−46.52, −3.83)MD −0.01, 95% CI (−0.19, 0.17)MD −1.16, 95% CI (−2.18, −0.13)

Factor Xa inhibitor (rivaroxaban)MD −133.66, 95% CI (−412.73, 145.40)MD −329.49, 95% CI (−1053.49, 394.52)MD 0.90, 95% CI (0.66, 1.13)MD −0.57, 95% CI (−1.69, 0.54)

Standard heparinMD −47.46, 95% CI (−107.27, 12.34)MD 23.42, 95% CI (−26.43, 73.27)MD 1.77, 95% CI (0.10, 3.44)MD 1.34, 95% CI (0.01, 2.67)

Thrombin inhibitorMD −300.97, 95% CI (−864.44, 262.71)MD −486.86, 95% CI (−1505.52, 531.81)MD 1.00, 95% CI (0.77, 1.23)MD −0.90, 95% CI (−2.56, 0.77)

CI, confidence interval; MD, mean difference; LMWHs, low molecular weight heparin; ALT, alanine aminotransferase; AST, aspartate aminotransferase.