Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study

Figure 2

Findings in the control group. The tumor remained hypointense on T1-weighted imaging (T1WI) at all time points. Similarly, the tumor was hyperintense on T2-weighted imaging (T2WI) throughout the experiment, with obvious liquefaction necrosis in the center of the tumor at day 14. At baseline, the tumor was hyperintense on diffused weighted-imaging (DWI), from 4 h to day 14. The DWI signal of the tumor gradually increased compared with the baseline, and the apparent diffusion coefficient (ADC) value of the entire tumor decreased from the baseline till day 4, after which it increased continuously until day 14 due to the liquefaction necrosis in the center of the tumor. However, the ADC value of the solid component of the tumor decreased gradually throughout the experiment.