Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study

Figure 6

Gross pathology of the rabbit VX2 liver tumor model and hematoxylin and eosin staining (×400) of the tumor in the M410 group at baseline, 4 h, 1, 4, 7, and 14 days after treatment. The intrahepatic mass is clear without capsule formation, and the tumor is grayish white and similar to a fish flesh. There are multipoints hemorrhagic foci in the tumor. The tumor was tough and clearly demarcated with the surrounding liver tissue. Corresponding under the light microscope observation, from the baseline to day 14, revealed that the tumor cells were larger in size, irregular in morphology, disordered in arrangement, and the nuclear atypia was obvious. Scattered patchy or focal necrosis and partial fusion were observed in the tumor tissue. The new capillaries in the interstitium were more abundant, and the fibrous connective tissue grew into bundles.