Effect of Hyperthermic Intraperitoneal Perfusion Chemotherapy Combined with Radical Surgery and Capecitabine on Stage III Gallbladder Cancer
Table 3
Multivariate analysis of factors contributing to overall survival in 78 GBC patients.
Variables
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
Age (≤60 vs. >60)
1.514 (0.923–2.483)
0.100
—
—
Gender (female vs. male)
1.309 (0.733–2.337)
0.363
—
—
Stones (negative vs. positive)
1.336 (0.801–2.229)
0.268
—
—
CEA (≤5 ng/mL vs. >5 ng/mL)
1.341 (0.699–2.573)
0.378
—
—
CA19-9 (≤35 U/L vs. >35 U/L)
0.793 (0.485–1.298)
0.357
—
—
CA125 (≤35 U/L vs. >35 U/L)
1.353 (0.806–2.274)
0.253
—
—
CA242 (≤20 U/L vs. >20 U/L)
0.923 (0.543–1.569)
0.768
—
—
Microvascular infiltration (negative vs. positive)
1.414 (0.786–2.542)
0.248
—
—
Lymph node metastasis (negative vs. positive)
1.841 (1.108–3.058)
0.019
1.813 (1.094–3.005)
0.024
Nerve invasion (negative vs. positive)
2.003 (1.188–3.378)
0.011
1.801 (1.082–2.998)
0.026
Treatment approach (control vs. HIPEC)
0.578 (0.354–0.971)
0.037
0.534 (0.320–0.892)
0.042
Note: univariate and multivariate analysis of prognostic factors in 78 GBC patients was included in the survival analysis. Statistical analyses were performed by Cox proportional hazards regression. A value < 0.05 was considered significant. CI, confidence interval.
